Hyperthermia prevents functional, histological and biochemical abnormalities induced during ileitis
Hyperthermia prevents functional, histological and biochemical abnormalities induced during ileitis
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高温可预防回肠炎期间引起的功能、组织学和生化异常
DOI：
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发表时间：
1999
影响因子：
3.5
通讯作者：
Donohue
中科院分区：
文献类型：
--
作者：
Goldhill;Stojadinovic;Kiang;Smallridge;Donohue
炎症性肠病与肠道动力改变和上皮损伤有关。热疗诱导热休克蛋白的表达，这是基本的细胞防御机制的组成部分，从而防止缺血损伤。在这里，我们研究高温是否可以预防炎症性肠病模型中改变的平滑肌功能和潜在的炎症。热休克(4 1.5 °C，5 min)诱导大鼠回肠热休克蛋白表达。加热或假处理2小时后，TNBS诱发回肠炎。4 h后取回肠标本，测定环状肌条的收缩反应，并测定热休克蛋白表达、白蛋白4的生成及损伤/炎症反应。回肠炎与环行肌对P物质的收缩反应增加有关，但与神经激动素A或神经刺激无关。高温诱导热休克蛋白表达，并阻止这种功能改变以及TNBS诱导的LTB4的产生，随后中性粒细胞的渗透和上皮损伤。因此，肠道炎症与平滑肌运动速动能控制的改变和炎性改变有关。高温可以阻止这些变化，并诱导热休克蛋白的表达。这些蛋白的药理诱导可能为治疗这两个方面的疾病提供一种新的临床策略。
Inflammatory bowel disease is associated with altered intestinal motility and epithelial damage. Hyperthermia induces heat shock protein expression, components of a basic cellular defence mechanism, and consequently prevents ischaemic damage. Here we investigate whether hyperthermia may prevent altered smooth muscle function as well as underlying inflammation in a model of inflammatory bowel disease. Ileal heat shock protein expression was induced in rats by hyperthermic shock (41.5 °C; 5 min). Two hours after heating or sham treatment, ileitis was evoked by TNBS. Ileal samples were taken 4 h later to determine the contractile response of circular muscle strips, and to measure heat shock protein expression, LTB4 generation and damage/inflammation. Ileitis was associated with an increase in the contractile response of circular muscle to substance P but not neurokinin A or nerve stimulation. Hyperthermia induced heat shock protein expression and also prevented this functional change as well as TNBS‐induced LTB4 production, subsequent infiltration of neutrophils and epithelial damage. Thus, intestinal inflammation is associated with alterations in tachykinergic control of smooth muscle as well as inflammatory changes. Hyperthermia prevents these changes and induces heat shock protein expression. Pharmacological induction of these proteins may offer a novel clinical strategy in treating both of these aspects of disease.
克罗恩病和溃疡性结肠炎患者 P 物质受体的差异表达。
影响因子：
29.4
作者：
Mantyh,CR;Vigna,SR;Bollinger,RR;Mantyh,PW;Maggio,JE;Pappas,TN
通讯作者：
Pappas,TN
DOI：
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发表时间：
1994-07
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
P. Hellstrom;K. Murthy;J. Grider;G. Makhlouf
通讯作者：
P. Hellstrom;K. Murthy;J. Grider;G. Makhlouf
兔小肠炎症模型中平滑肌肠神经调节的变化。
DOI：
10.1152/ajpgi.1995.268.5.g823
发表时间：
1995
期刊：
The American journal of physiology.
影响因子：
--
作者：
Goldhill,JM;Sanders,KM;Sjogren,R;Shea-Donohue,T
通讯作者：
Shea-Donohue,T