Obesity and albuminuria among adults with type 2 diabetes: the Look AHEAD (Action for Health in Diabetes) Study.
Obesity and albuminuria among adults with type 2 diabetes: the Look AHEAD (Action for Health in Diabetes) Study.
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DOI：
10.2337/dc08-2059
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发表时间：
2009-05
期刊：
影响因子：
16.2
通讯作者：
Look Ahead Research Group
中科院分区：
文献类型：
--
作者：
Kramer H;Reboussin D;Bertoni AG;Marcovina S;Lipkin E;Greenway FL 3rd;Brancati FL;Look Ahead Research Group
目的：确定成人2型糖尿病患者的肥胖测量与蛋白尿之间的关系。在前瞻性（糖尿病健康行动）研究中，4985名参与者测量了BMI和腰围，1351名参与者通过全身DEXA扫描测量了总体脂率。在调整协变量的同时，使用逻辑回归分析计算BMI、腰围和总体脂百分比四分位数的蛋白尿几率。校正协变量后，BMI（比值比[OR] 1.72 [95% CI 1.40-2.11]）和腰围（比值比[OR] 1.75 [95% CI 1.42-2.15]）的最高四分位数与蛋白尿显著相关。在任何模型中，没有发现总脂肪百分比和蛋白尿之间的关联。体重指数增加和腹部肥胖与2型糖尿病超重和肥胖成人的蛋白尿有关。
To determine the association between obesity measures and albuminuria in adults with type 2 diabetes. In the Look AHEAD (Action for Health in Diabetes) Study, BMI and waist circumference were measured among 4,985 participants while total percent body fat was measured by whole-body DEXA scans among 1,351 participants. Odds of albuminuria by quartiles of BMI, waist circumference, and percent total body fat were calculated using logistic regression analysis while adjusting for covariates. The highest quartile of BMI (odds ratio [OR] 1.72 [95% CI 1.40–2.11]) and waist circumference (OR 1.75 [95% CI 1.42–2.15]) was significantly associated with albuminuria compared with the lowest quartile after adjustment for covariates. No associations were noted between quartiles of percent total body fat and albuminuria in any model. Increased BMI and abdominal obesity are associated with albuminuria in overweight and obese adults with type 2 diabetes.
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影响因子：
4.9
作者：
Heshka, S.;Ruggiero, A.;Schwartz, A. V.
通讯作者：
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影响因子：
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作者：
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DOI：
10.1016/s0197-2456(03)00064-3
发表时间：
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期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Wing, Rena