Interactions between coagulation and complement--their role in inflammation.
Interactions between coagulation and complement--their role in inflammation.
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DOI：
10.1007/s00281-011-0280-x
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发表时间：
2012-01
影响因子：
9
通讯作者：
Lambris, John D.
中科院分区：
文献类型：
--
作者：
Oikonomopoulou, Katerina;Ricklin, Daniel;Ward, Peter A.;Lambris, John D.
在临床和实验环境中，长期以来都观察到凝血、纤溶和补体系统激活产物的平行表达。这些级联反应中各个成分之间的一些相互联系也已被描述，而且共享调节因子的名单还在不断增加。止血和炎症介质在同一微环境中的共存和相互作用通常确保了在屏障受损情况下宿主免疫防御的成功。然而，一个或两个系统中级联活动或抑制剂功能的失调可能导致疾病的临床表现，如败血症、系统性红斑狼疮或缺血 - 再灌注损伤，并伴有严重的血栓和/或炎症并发症。了解补体激活与血栓形成之间的精确关系可能有助于开发新的治疗方法，并改善以补体相关炎症反应为特征的血栓性疾病患者的临床管理。
The parallel expression of activation products of the coagulation, fibrinolysis, and complement systems has long been observed in both clinical and experimental settings. Several interconnections between the individual components of these cascades have also been described, and the list of shared regulators is expanding. The coexistence and interplay of hemostatic and inflammatory mediators in the same microenvironment typically ensures a successful host immune defense in compromised barrier settings. However, dysregulation of the cascade activities or functions of inhibitors in one or both systems can result in clinical manifestations of disease, such as sepsis, systemic lupus erythematosus, or ischemia–reperfusion injury, with critical thrombotic and/or inflammatory complications. An appreciation of the precise relationship between complement activation and thrombosis may facilitate the development of novel therapeutics, as well as improve the clinical management of patients with thrombotic conditions that are characterized by complement-associated inflammatory responses.
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DOI：
10.4049/jimmunol.0903678
发表时间：
2010-11-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Amara U;Flierl MA;Rittirsch D;Klos A;Chen H;Acker B;Brückner UB;Nilsson B;Gebhard F;Lambris JD;Huber-Lang M
通讯作者：
Huber-Lang M
DOI：
10.1165/rcmb.2004-0274oc
发表时间：
2005-05-01
影响因子：
6.4
作者：
Dulon, S;Leduc, D;Chignard, M
通讯作者：
Chignard, M
影响因子：
56.9
作者：
DAVIE, EW;RATNOFF, OD
通讯作者：
RATNOFF, OD
影响因子：
64.8
作者：
Coughlin, SR
通讯作者：
Coughlin, SR
影响因子：
4.8
作者：
Bamberg, Claire E.;Mackay, Charles R.;Gerard, Norma P.
通讯作者：
Gerard, Norma P.