Relation of fever intensity and antipyretic use with specific antibody response after two doses of the BNT162b2 mRNA vaccine.
Relation of fever intensity and antipyretic use with specific antibody response after two doses of the BNT162b2 mRNA vaccine.
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DOI：
10.1016/j.vaccine.2022.02.025
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发表时间：
2022-03-18
期刊：
影响因子：
5.5
通讯作者：
Kuwano H
中科院分区：
文献类型：
--
作者：
Tani N;Chong Y;Kurata Y;Gondo K;Oishi R;Goto T;Minami J;Onozawa K;Nagano S;Shimono N;Ikematsu H;Kuwano H
BNT162b2 COVID-19疫苗的反应原性已被普遍报道，解热药物通常用于减轻不良反应。反应性事件和特异性抗体反应之间可能存在的关联尚未得到充分研究，使用退烧药的影响也未得到充分研究。采集无COVID-19病史的医院医护人员的血清样本，测定两剂后的SARS-CoV-2尖峰特异性IgG滴度。在每次给药后5天使用自我报告日记报告一天内征求的不良反应程度，包括最高体温。将5天最高体温分为<37.0℃、37.0 ~ 37.9℃、≥38.0℃3个等级。使用问卷报告自我解热药物。335名参与者的数据可供分析。多因素分析发现，第二次给药后发热程度（标准化系数β = 0.301, p < 0.0001）、女性性别（β = 0.196, p = 0.0014）和年龄（β = -0.119, p = 0.0495）与IgG滴度有显著相关性。按性别和年龄分析，第二次接种后发热程度与IgG滴度也呈正相关。使用退烧药不影响IgG滴度，与发热程度无关。第二次剂量后的发热强度与IgG滴度相关，退热药物可能有助于减轻不良反应的痛苦，而不会干扰获得足够的抗体反应。
The reactogenicity of BNT162b2 COVID-19 vaccine has been commonly reported and antipyretic medications are often used for mitigating adverse reactions. Possible associations between the reactogenicity events and specific antibody responses have not been fully investigated, nor has the influence of using antipyretics. Serum samples were collected from hospital healthcare workers with no COVID-19 history and the SARS-CoV-2 spike-specific IgG titer after two doses was measured. Degree of solicited adverse reactions in a day, including the highest body temperature, were reported using a self-reporting diary for five days after each dose. The highest body temperature during the five days was divided into three grades (<37.0 °C, 37.0–37.9 °C, or ≥ 38.0 °C). Self-medicated antipyretics were reported using a questionnaire. The data of 335 participants were available for analysis. Multivariate analysis extracted the fever grade after the second dose (standardized coefficient beta = 0.301, p < 0.0001), female sex (beta = 0.196, p = 0.0014), and age (beta = -0.119, p = 0.0495) as being significantly correlated with the IgG titers. The positive correlation of the fever grade after the second dose with the IgG titers was also observed when analyzed by sex and age. The use of antipyretics did not interfere with the IgG titers irrespective of the fever grade. The fever intensity after the second dose was associated with the IgG titer and antipyretic medications may be beneficial to mitigate the suffering from adverse reactions, without interfering with the acquisition of sufficient antibody responses.
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DOI：
10.1056/nejmoa2034577
发表时间：
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期刊：
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影响因子：
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10.1016/j.lanepe.2021.100208
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影响因子：
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10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
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