Differentiated Daughter Cells Regulate Stem Cell Proliferation and Fate through Intra-tissue Tension.
Differentiated Daughter Cells Regulate Stem Cell Proliferation and Fate through Intra-tissue Tension.
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DOI：
10.1016/j.stem.2020.11.002
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发表时间：
2021-03-04
期刊：
影响因子：
23.9
通讯作者：
Lechler T
中科院分区：
文献类型：
--
作者：
Ning W;Muroyama A;Li H;Lechler T
基底干细胞为表皮的发育、稳态和再生提供燃料。这些细胞的增殖和命运决定受到其微环境的高度调节，包括基底膜和下层间充质细胞。基底祖细胞产生产生表皮屏障的分化后代。在这里，我们提出的数据，分化后代也调节增殖，分化和迁移的基础祖细胞。使用两种不同的小鼠品系，我们发现，增加分化细胞的收缩性导致干细胞的非细胞自主过度增殖，并阻止它们向毛囊谱系的承诺。在毛基板形态发生过程中，分化细胞的收缩性增加导致基底祖细胞的运动受损，并减少了成黑素细胞的迁移。这些数据表明，组织内张力调节干细胞增殖、命运决定和迁移，并且分化的表皮角质形成细胞是调节皮肤发育和稳态的干细胞生态位的组分。
Basal stem cells fuel development, homeostasis, and regeneration of the epidermis. The proliferation and fate decisions of these cells are highly regulated by their microenvironment, including the basement membrane and underlying mesenchymal cells. Basal progenitors give rise to differentiated progeny that generate the epidermal barrier. Here, we present data that differentiated progeny also regulate the proliferation, differentiation, and migration of basal progenitor cells. Using two distinct mouse lines, we found that increasing contractility of differentiated cells resulted in non-cell autonomous hyperproliferation of stem cells and prevented their commitment to a hair follicle lineage. Increased contractility of differentiated cells resulted in impaired movement of basal progenitors during hair placode morphogenesis, and diminished migration of melanoblasts. These data suggest that intra-tissue tension regulates stem cell proliferation, fate decisions and migration, and that differentiated epidermal keratinocytes are a component of the stem cell niche that regulates development and homeostasis of the skin.
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影响因子：
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