Transcriptional repression shapes the identity and function of tissue macrophages.
Transcriptional repression shapes the identity and function of tissue macrophages.
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DOI：
10.1002/2211-5463.13269
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发表时间：
2021-12
期刊：
影响因子：
2.6
通讯作者：
Nagy L
中科院分区：
文献类型：
--
作者：
Bene K;Halasz L;Nagy L
不断变化的细胞外和细胞内微环境需要快速的细胞命运决定，这些决定主要在转录水平上进行精确的调控。免疫系统的细胞组成部分是细胞如何响应和适应不同环境刺激的极好例子。先天免疫细胞如巨噬细胞能够通过激活和抑制特定基因来调节其转录程序和表观遗传调控网络，使其能够快速响应快速变化的环境。组织巨噬细胞是哺乳动物中不同免疫和非免疫细胞介导的生理机制的重要组成部分，并且是研究转录调控机制的广泛使用的模型。因此，关键是要解开不同的转录激活因子，抑制因子和辅助调节因子，它们在体内平衡过程中以及在影响大量人群的疾病（如代谢综合征，免疫缺陷和肿瘤发展）中起决定组织巨噬细胞身份和功能的作用。在这篇综述中，我们将重点介绍在生理条件下组织巨噬细胞发育和功能中发挥作用的转录抑制因子。组织巨噬细胞是通过其效应功能维持组织稳态和完整性的重要细胞组分。组织驻留巨噬细胞如肺泡、脾红髓、肠巨噬细胞和小胶质细胞具有重叠功能。组织驻留巨噬细胞亚型的身份和功能由不同的转录激活因子和阻遏蛋白组成。在这篇综述中，我们将重点放在阻遏物。
The changing extra‐ and intracellular microenvironment calls for rapid cell fate decisions that are precisely and primarily regulated at the transcriptional level. The cellular components of the immune system are excellent examples of how cells respond and adapt to different environmental stimuli. Innate immune cells such as macrophages are able to modulate their transcriptional programs and epigenetic regulatory networks through activation and repression of particular genes, allowing them to quickly respond to a rapidly changing environment. Tissue macrophages are essential components of different immune‐ and nonimmune cell‐mediated physiological mechanisms in mammals and are widely used models for investigating transcriptional regulatory mechanisms. Therefore, it is critical to unravel the distinct sets of transcription activators, repressors, and coregulators that play roles in determining tissue macrophage identity and functions during homeostasis, as well as in diseases affecting large human populations, such as metabolic syndromes, immune‐deficiencies, and tumor development. In this review, we will focus on transcriptional repressors that play roles in tissue macrophage development and function under physiological conditions. Tissue macrophages are essential cellular components in maintaining tissue homeostasis and integrity through their effector functions. Tissue‐resident macrophages such as the alveolar, splenic red pulp, intestinal macrophages, and microglia have overlapping function. The identity and function of tissue‐resident macrophage subtypes are orchestrated by distinct sets of transcriptional activator and repressor proteins. In this review, we focus on repressors.
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影响因子：
64.5
作者：
Haldar M;Kohyama M;So AY;Kc W;Wu X;Briseño CG;Satpathy AT;Kretzer NM;Arase H;Rajasekaran NS;Wang L;Egawa T;Igarashi K;Baltimore D;Murphy TL;Murphy KM
通讯作者：
Murphy KM
影响因子：
5.2
作者：
Czimmerer Z;Halasz L;Nagy L
通讯作者：
Nagy L
影响因子：
29
作者：
Barish GD;Yu RT;Karunasiri MS;Becerra D;Kim J;Tseng TW;Tai LJ;Leblanc M;Diehl C;Cerchietti L;Miller YI;Witztum JL;Melnick AM;Dent AL;Tangirala RK;Evans RM
通讯作者：
Evans RM
影响因子：
64.5
作者：
Gosselin D;Link VM;Romanoski CE;Fonseca GJ;Eichenfield DZ;Spann NJ;Stender JD;Chun HB;Garner H;Geissmann F;Glass CK
通讯作者：
Glass CK
影响因子：
8.7
作者：
Bain CC;Mowat AM
通讯作者：
Mowat AM