Increased Expression of Interferon-Induced Transmembrane 3 (IFITM3) in Stroke and Other Inflammatory Conditions in the Brain.
Increased Expression of Interferon-Induced Transmembrane 3 (IFITM3) in Stroke and Other Inflammatory Conditions in the Brain.
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DOI：
10.3390/ijms23168885
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发表时间：
2022-08-10
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
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作者：
小胶质细胞是大脑的固有免疫细胞，随着年龄的增长和疾病的发生，它的反应变得更加强烈。与大脑中的其他细胞类型合作，小胶质细胞可以通过将其表型改变为修复性小胶质细胞来促进中风或其他神经退行性疾病后的恶化结果以及恢复过程。最近，IFITM3（“干扰素诱导的跨膜”家族的成员）已被揭示为淀粉样蛋白病理学和神经炎症之间的分子介导剂。IFITM3在神经胶质细胞，特别是中风后的小胶质细胞中的表达还没有很好的描述。在这里，我们提出的证据表明，缺血性中风导致老年人大脑中IFITM 3表达增加沿着小胶质细胞活化标记基因的增加。为了进一步验证中风后脑中IFITM3的诱导，将原代小胶质细胞和小胶质细胞样细胞暴露于各种炎症条件，其显著诱导IFITM3以及其他炎症标志物。这些发现表明IFITM3在诱导炎症中的关键作用。我们对中风后小胶质细胞和老年大脑中IFITM3表达的研究结果可以为IFITM3在各种神经退行性疾病中的作用奠定基础，特别是那些在老年大脑中普遍存在或增强的疾病。
Microglia, the resident innate immune cells of the brain, become more highly reactive with aging and diseased conditions. In collaboration with other cell types in brains, microglia can contribute both to worsened outcome following stroke or other neurodegenerative diseases and to the recovery process by changing their phenotype toward reparative microglia. Recently, IFITM3 (a member of the “interferon-inducible transmembrane” family) has been revealed as a molecular mediator between amyloid pathology and neuroinflammation. Expression of IFITM3 in glial cells, especially microglia following stroke, is not well described. Here, we present evidence that ischemic stroke causes an increase in IFITM3 expression along with increased microglial activation marker genes in aged brains. To further validate the induction of IFITM3 in post-stroke brains, primary microglia and microglial-like cells were exposed to a variety of inflammatory conditions, which significantly induced IFITM3 as well as other inflammatory markers. These findings suggest the critical role of IFITM3 in inducing inflammation. Our findings on the expression of IFITM3 in microglia and in aged brains following stroke could establish the basic foundations for the role of IFITM3 in a variety of neurodegenerative diseases, particularly those that are prevalent or enhanced in the aged brain.
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影响因子：
32.4
作者：
Roy, Ethan R.;Chiu, Gabriel;Li, Sanming;Propson, Nicholas E.;Kanchi, Rupa;Wang, Baiping;Coarfa, Cristian;Zheng, Hui;Cao, Wei
通讯作者：
Cao, Wei
影响因子：
3
作者：
Hong SH;Hong JH;Lahey MT;Zhu L;Stephenson JM;Marrelli SP
通讯作者：
Marrelli SP
影响因子：
5.3
作者：
Jäkel S;Dimou L
通讯作者：
Dimou L
影响因子：
64.8
作者：
Hur JY;Frost GR;Wu X;Crump C;Pan SJ;Wong E;Barros M;Li T;Nie P;Zhai Y;Wang JC;Tcw J;Guo L;McKenzie A;Ming C;Zhou X;Wang M;Sagi Y;Renton AE;Esposito BT;Kim Y;Sadleir KR;Trinh I;Rissman RA;Vassar R;Zhang B;Johnson DS;Masliah E;Greengard P;Goate A;Li YM
通讯作者：
Li YM
DOI：
10.1146/annurev-virology-092818-015756
发表时间：
2019-01-01
期刊：
ANNUAL REVIEW OF VIROLOGY, VOL 6, 2019
影响因子：
--
作者：
Schoggins, John W.
通讯作者：
Schoggins, John W.