Differences in survival between colon and rectal cancer from SEER data.
Differences in survival between colon and rectal cancer from SEER data.
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DOI：
10.1371/journal.pone.0078709
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Lee JC
中科院分区：
文献类型：
--
作者：
Lee YC;Lee YL;Chuang JP;Lee JC
人们对结直肠癌或结肠癌和直肠癌知之甚少。它们是同一种疾病还是不同的疾病？这项流行病学研究的目的是利用最近的国家癌症监测数据来比较结肠癌和直肠癌的特征。数据包括来自监测、流行病学和最终结果计划 (SEER) 数据库的结直肠癌（1995-2008 年）。仅包括腺癌进行分析。总共分析了 372,130 名患者，中位随访时间为 32 个月。评估了同一阶段的结肠癌和直肠癌患者的平均生存期。大约 35% 的患者有分期信息。其中，结肠癌患者的IIB期生存期比直肠癌患者高出4个月。在IIIC期和IV期，直肠癌患者的生存期比结肠癌患者长约3个月。 IIB期结直肠癌患者的预后比IIIA期和IIIB期结直肠癌患者的预后较差。调整年龄、性别和种族后，IIB期结肠癌患者的生存率高于直肠癌，但在IIIC和IV期，直肠癌患者的生存率高于结肠癌。该研究因其回顾性而受到限制。这是一项基于人群的研究。直肠癌的预后并不比结肠癌差。局部晚期结直肠癌的预后比局部区域淋巴结转移差。 IIB 期可能需要更积极的化疗，且不低于 III 期。
Little is known about colorectal cancer or colon and rectal cancer. Are they the same disease or different diseases? The aim of this epidemiology study was to compare the features of colon and rectal cancer by using recent national cancer surveillance data. Data included colorectal cancer (1995–2008) from the Surveillance, Epidemiology, and End Results Program (SEER) database. Only adenocarcinoma was included for analysis. A total of 372,130 patients with a median follow-up of 32 months were analyzed. Mean survival of patients with the same stage of colon and rectal cancer was evaluated. Around 35% of patients had stage information. Among them, colon cancer patients had better survival than those with rectal cancer, by a margin of 4 months in stage IIB. In stage IIIC and stage IV, rectal cancer patients had better survival than colon cancer patients, by about 3 months. Stage IIB colorectal cancer patients had a poorer prognosis than those with stage IIIA and IIIB colorectal cancer. After adjustment of age, sex and race, colon cancer patients had better survival than rectal cancer of stage IIB, but in stage IIIC and IV, rectal cancer patients had better survival than colon cancer. The study is limited by its retrospective nature. This was a population-based study. The prognosis of rectal cancer was not worse than that of colon cancer. Local advanced colorectal cancer had a poorer prognosis than local regional lymph node metastasis. Stage IIB might require more aggressive chemotherapy, and no less than that for stage III.
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影响因子：
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作者：
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通讯作者：
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Heliövaara, M
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通讯作者：
Urosevic N