Conditioned place preference for cocaine and methylphenidate in female mice from lines selectively bred for high voluntary wheel‐running behavior
Conditioned place preference for cocaine and methylphenidate in female mice from lines selectively bred for high voluntary wheel‐running behavior
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雌性小鼠对可卡因和哌醋甲酯的条件性位置偏好，这些小鼠来自针对高自愿轮跑行为选择性培育的品系
DOI：
10.1111/gbb.12700
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发表时间：
2020
影响因子：
3.1
通讯作者：
Ramirez, Jocelyn L.
中科院分区：
文献类型：
--
作者：
Schmill, Margaret P.;Cadney, Marcell D.;Thompson, Zoe;Hiramatsu, Layla;Albuquerque, Ralph L.;McNamara, Monica P.;Castro, Alberto A.;Kay, Jarren C.;Buenaventura, Darrius G.;Ramirez, Jocelyn L.
行为成瘾有多种形式，包括暴饮暴食、赌博和过度运动。所有成瘾都有一个共同的机制，涉及自然奖励回路和强化学习的激活，但自然奖励和药物奖励的动机在多大程度上共享类似的神经遗传机制仍然未知。一种独特的小鼠遗传模型，其中选择性繁殖了四个重复系的雌性小鼠（>76代），用于高自愿车轮运行（High Runner或HR线）以及四个非选择的对照（C）线用于检验高运动动机与可卡因更大奖励相关的假设。（20 mg/kg）和哌醋甲酯（10 mg/kg）的小鼠，使用条件性位置偏爱（CPP）测试。HR小鼠每天跑的圈数是C小鼠的三倍，但它们对其他奖励的动机增加的程度是未知的。HR和C小鼠对可卡因和哌甲酯均显示出显著的CPP，但两种药物的线型之间无统计学差异。总之，结果表明，选择性繁殖增加自愿跑步已经改变了大脑中的奖励回路，以增加跑步的动机，而不影响可卡因或哌甲酯的奖励。
Behavioral addictions can come in many forms, including overeating, gambling and overexercising. All addictions share a common mechanism involving activation of the natural reward circuit and reinforcement learning, but the extent to which motivation for natural and drug rewards share similar neurogenetic mechanisms remains unknown. A unique mouse genetic model in which four replicate lines of female mice were selectively bred (>76 generations) for high voluntary wheel running (High Runner or HR lines) alongside four non‐selected control (C) lines were used to test the hypothesis that high motivation for exercise is associated with greater reward for cocaine (20 mg/kg) and methylphenidate (10 mg/kg) using the conditioned place preference (CPP) test. HR mice run ~three times as many revolutions/day as C mice, but the extent to which they have increased motivation for other rewards is unknown. Both HR and C mice displayed significant CPP for cocaine and methylphenidate, but with no statistical difference between linetypes for either drug. Taken together, results suggest that selective breeding for increased voluntary running has modified the reward circuit in the brain in a way that increases motivation for running without affecting cocaine or methylphenidate reward.
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影响因子：
9.2
作者：
Knab AM;Lightfoot JT
通讯作者：
Lightfoot JT
药物成瘾的行为神经科学
影响因子：
5.4
作者：
D. Self;J. Staley;M. Geyer;B. Ellenbroek;C. Marsden
通讯作者：
C. Marsden
影响因子：
17.7
作者：
Volkow, ND;Wang, GJ;Pappas, N
通讯作者：
Pappas, N
体育活动水平的生物/遗传调节：Genbiopac的共识。
影响因子：
4.1
作者：
Lightfoot JT;DE Geus EJC;Booth FW;Bray MS;DEN Hoed M;Kaprio J;Kelly SA;Pomp D;Saul MC;Thomis MA;Garland T Jr;Bouchard C
通讯作者：
Bouchard C
影响因子：
1.9
作者：
Kanarek, Robin B.;D'Anci, Kristen E.;Jurdak, Nicole;Mathes, Wendy Foulds
通讯作者：
Mathes, Wendy Foulds