Running and addiction: precipitated withdrawal in a rat model of activity-based anorexia.
Running and addiction: precipitated withdrawal in a rat model of activity-based anorexia.
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DOI：
10.1037/a0015896
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发表时间：
2009-08
影响因子：
1.9
通讯作者：
Mathes, Wendy Foulds
中科院分区：
文献类型：
--
作者：
Kanarek, Robin B.;D'Anci, Kristen E.;Jurdak, Nicole;Mathes, Wendy Foulds
体育活动可以改善心血管健康，增强肌肉和骨骼，刺激神经可塑性，并促进幸福感和自尊感。然而，当运动走向极端时，它可能会发展成一种类似上瘾的行为。为了进一步评估身体活动的成瘾潜力，本实验评估了大鼠的跑轮活动是否会导致类似于长期服用吗啡后观察到的身体依赖性。活跃的雄性和雌性大鼠被安置在跑轮中，不活跃的雄性和雌性大鼠被安置在标准笼子中。适应居住条件后，活跃和不活跃的大鼠每天进食一小时或二十四小时。此外，一组不活动的大鼠与限制食物的活动大鼠前一天消耗的食物量配对喂养。每天只喂食一小时的活跃和不活跃的老鼠会减少食物摄入量并减轻体重。此外，限制食物的活动大鼠增加了跑轮活动。当限食活动大鼠体重达到限食前体重的80%时，给大鼠注射1.0 mg/kg纳洛酮，观察其是否有突然戒断症状，评价其身体依赖性。跑步强度与戒断症状的严重程度之间存在直接关系。在雄性和雌性中，活跃的食物限制大鼠表现出最多数量的戒断症状，其次是活跃的随意进食的大鼠。相比之下，在不活动的大鼠中仅观察到轻微的戒断症状。这些发现支持这样的假设：运动引起的内源性阿片肽增加的作用方式类似于长期服用阿片类药物。
Physical activity improves cardiovascular health, strengthens muscles and bones, stimulates neuroplasticity, and promotes feelings of well-being and self-esteem. However, when taken to extremes, exercise can develop into an addictive-like behavior. To further assess the addictive potential of physical activity, the present experiments assessed whether running wheel activity in rats would lead to physical dependence similar to that observed after chronic morphine administration. Active male and female rats were housed in running wheels, and inactive male and female rats, in standard cages. After adaptation to the housing conditions, active and inactive rats were given food for either one hour or 24 hours a day. Additionally, a group of inactive rats was pair-fed the amount of food consumed on the previous day by food-restricted active rats. Active and inactive rats fed for only one hour a day decreased food intake and lost weight. Additionally, food-restricted active rats increased running wheel activity. When the body weight of food-restricted active rats reached 80% of their pre-restriction weight, physical dependence was assessed by injecting rats with 1.0 mg/kg naloxone, and observing them for symptoms of precipitated withdrawal. There was a direct relationship between the intensity of running and the severity of withdrawal symptoms. In both males and females, active food-restricted rats displayed the largest number of withdrawal symptoms, followed by the active rats given ad libitum access to food. In contrast, only minimal withdrawal symptoms were observed in inactive rats. These findings support the hypothesis that exercise-induced increases in endogenous opioid peptides act in a manner similar to chronic administration of opiate drugs.
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DOI：
10.7600/jspfsm1949.52.159
发表时间：
2003-04-01
影响因子：
--
作者：
Asahina, S;Asano, K;Sato, M
通讯作者：
Sato, M
影响因子：
1.9
作者：
Boakes, RA;Mills, KJ;Single, JP
通讯作者：
Single, JP
DOI：
10.1097/00005768-199812000-00003
发表时间：
1998-12-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Goldfarb, AH;Jamurtas, AZ;Brown, DA
通讯作者：
Brown, DA
影响因子：
1.9
作者：
Franko, Debra L.;Dorer, David J.;Herzog, David B.
通讯作者：
Herzog, David B.
DOI：
10.1037/h0031588
发表时间：
1971-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
COLLIER, G;HIRSCH, E
通讯作者：
HIRSCH, E