Cell death in Streptococcus mutans biofilms: a link between CSP and extracellular DNA.
Cell death in Streptococcus mutans biofilms: a link between CSP and extracellular DNA.
复制标题
DOI：
10.1111/j.1574-6968.2009.01758.x
复制
发表时间：
2009-10
影响因子：
2.1
通讯作者：
Lévesque CM
中科院分区：
文献类型：
--
作者：
Perry JA;Cvitkovitch DG;Lévesque CM
链球菌能力刺激肽（CSPs）曾经被认为是被动地传达种群密度的一个经典的称为群体感应的过程。然而，最近的证据表明，这些肽也可能是可诱导的“警报器”，能够在种群中传递复杂的信息，包括在压力条件下诱导利他细胞自杀。我们之前已经描述了变形链球菌（一种口腔菌群的致龋居民）的警报器反应，其中一种新的细菌素样肽导致一部分人群的细胞死亡。我们在这项工作的目的是表征变形链球菌对细胞死亡的免疫机制。为了实现这一目标，我们已经确定了诱导免疫的条件，并确定了负责免疫差异（和保护性）表达的调节系统。我们还发现，CSP诱导的死亡通过将染色体DNA释放到细胞外基质中，有助于变形链球菌生物膜的形成，这为CSP在变形链球菌生物膜形成中的作用提供了一个长期寻求的机制解释。
Streptococcal competence-stimulating peptides (CSPs) were once thought to passively communicate population density in a process known classically as quorum sensing. However, recent evidence has shown that these peptides may also be inducible ‘alarmones,’ capable of conveying sophisticated messages in a population including the induction of altruistic cellular suicide under stressful conditions. We have previously characterized the alarmone response in Streptococcus mutans, a cariogenic resident of the oral flora, in which a novel bacteriocin-like peptide causes cell death in a subset of the population. Our objective in this work was to characterize the mechanism of immunity to cell death in S. mutans. Toward this goal, we have identified the conditions under which immunity is induced, and identified the regulatory system responsible for differential (and protective) expression of immunity. We also showed that CSP-induced death contributes to S. mutans biofilm formation through the release of chromosomal DNA into the extracellular matrix, providing a long sought-after mechanistic explanation for the role of CSP in S. mutans biofilm formation.
登录
查看更多内容
影响因子：
3.2
作者：
Petersen, FC;Tao, L;Scheie, AA
通讯作者：
Scheie, AA
影响因子：
56.9
作者：
Whitchurch, CB;Tolker-Nielsen, T;Mattick, JS
通讯作者：
Mattick, JS
影响因子：
3.2
作者：
Li, YH;Hanna, MN;Cvitkovitch, DG
通讯作者：
Cvitkovitch, DG
影响因子：
3.6
作者：
Perry JA;Jones MB;Peterson SN;Cvitkovitch DG;Lévesque CM
通讯作者：
Lévesque CM
影响因子：
3.2
作者：
LAWRENCE, JR;KORBER, DR;CALDWELL, DE
通讯作者：
CALDWELL, DE