Rikkunshito, a ghrelin potentiator, ameliorates anorexia-cachexia syndrome.
Rikkunshito, a ghrelin potentiator, ameliorates anorexia-cachexia syndrome.
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rikkunshito是一种变形蛋白增强剂，可以改善厌食症 - 核综合征。
DOI：
10.3389/fphar.2014.00271
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发表时间：
2014
影响因子：
5.6
通讯作者：
Uezono Y
中科院分区：
文献类型：
--
作者：
Fujitsuka N;Uezono Y
厌食-恶病质综合征发生在各种慢性病的晚期，在这些疾病中，患者表现出食物摄入量减少、体重减轻和肌肉组织浪费。对于这些患者来说，这种综合征是一个严重的问题，导致发病率和死亡率的增加。目前治疗厌食症-恶病质的药物治疗效果有限。日本草药Rikkunshito经常被用来治疗厌食症和上胃肠道(GI)疾病。因此，利空施托有望对厌食-恶病质综合征患者的治疗有所裨益。本文就利坤施托治疗厌食症-恶病质的作用及其作用机制作一综述。持续的食欲不振会导致身体能量储存的逐渐耗尽，这常常与恶病质有关。因此，调节食欲和能量平衡对于治疗恶病质至关重要。Ghrelin主要由胃分泌，在启动摄食、控制胃肠运动、调节能量消耗等方面起着重要作用。最近的临床和基础科学研究表明，利空施托的关键机制是内源性Ghrelin活性的基础。有趣的是，Rikunshito的几个成分针对多个胃和中枢部位，并调节Ghrelin的分泌、受体敏化和降解。Rikunshito对治疗厌食症、体重减轻、肌肉萎缩和焦虑相关行为有效。此外，在恶病质动物模型中，观察到利空施托的治疗可以延长存活期。使用Ghrelin信号增强剂，如Rikunshito，可能代表着治疗厌食症-恶病质综合征的一种新方法。
Anorexia–cachexia syndrome develops during the advanced stages of various chronic diseases in which patients exhibit a decreased food intake, weight loss, and muscle tissue wasting. For these patients, this syndrome is a critical problem leading to an increased rate of morbidity and mortality. The present pharmacological therapies for treating anorexia–cachexia have limited effectiveness. The Japanese herbal medicine rikkunshito is often prescribed for the treatment of anorexia and upper gastrointestinal (GI) disorders. Thus, rikkunshito is expected to be beneficial for the treatment of patients with anorexia–cachexia syndrome. In this review, we summarize the effects of rikkunshito and its mechanisms of action on anorexia–cachexia. Persistent loss of appetite leads to a progressive depletion of body energy stores, which is frequently associated with cachexia. Consequently, regulating appetite and energy homeostasis is critically important for treating cachexia. Ghrelin is mainly secreted from the stomach, and it plays an important role in initiating feeding, controlling GI motility, and regulating energy expenditure. Recent clinical and basic science studies have demonstrated that the critical mechanism of rikkunshito underlies endogenous ghrelin activity. Interestingly, several components of rikkunshito target multiple gastric and central sites, and regulate the secretion, receptor sensitization, and degradation of ghrelin. Rikkunshito is effective for the treatment of anorexia, body weight loss, muscle wasting, and anxiety-related behavior. Furthermore, treatment with rikkunshito was observed to prolong survival in an animal model of cachexia. The use of a potentiator of ghrelin signaling, such as rikkunshito, may represent a novel approach for the treatment of anorexia–cachexia syndrome.
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影响因子：
29.4
作者：
Date, Y;Murakami, N;Nakazato, M
通讯作者：
Nakazato, M
影响因子：
4.8
作者：
DeBoer, Mark D.;Zhu, Xin Xia;Marks, Daniel L.
通讯作者：
Marks, Daniel L.
DOI：
10.1016/s0006-291x(02)03028-0
发表时间：
2003-02-07
影响因子：
3.1
作者：
Hanada, T;Toshinai, K;Nakazato, M
通讯作者：
Nakazato, M
影响因子：
3.3
作者：
Currow, David C.;Abernethy, Amy P.
通讯作者：
Abernethy, Amy P.
影响因子：
5.8
作者：
Gnanapavan, S;Kola, B;Korbonits, M
通讯作者：
Korbonits, M