Catecholamines in the bed nucleus of the stria terminalis reciprocally respond to reward and aversion.
Catecholamines in the bed nucleus of the stria terminalis reciprocally respond to reward and aversion.
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DOI：
10.1016/j.biopsych.2011.10.017
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发表时间：
2012-02-15
影响因子：
10.6
通讯作者：
Wightman, R. Mark
中科院分区：
文献类型：
--
作者：
Park, Jinwoo;Wheeler, Robert A.;Fontillas, Khristy;Keithley, Richard B.;Carelli, Regina M.;Wightman, R. Mark
关键词：
传统上，去甲肾上腺素与压力反应有关，而多巴胺与奖励有关。这两种儿茶酚胺都存在于终纹床核（BNST）和下丘脑-垂体-肾上腺轴中，终纹床核是皮质/边缘系统中心之间延伸的杏仁核中的脑中继核。尽管这种共定位，鲜为人知的是亚秒级的BNST在响应显着刺激的次区域中的儿茶酚胺信号。在大鼠BNST内使用快速扫描循环伏安法在碳纤维微电极在BNST的响应显着刺激的子区域细胞外儿茶酚胺浓度的变化进行了测量。一个离散的次区域分布的释放事件，观察到不同的儿茶酚胺在这个核。此外，奖励和厌恶tastants诱发的BNST去甲肾上腺素和多巴胺释放的反向模式。一个厌恶的刺激，奎宁，激活去甲肾上腺素能信号，但抑制多巴胺能信号，而可口的刺激，蔗糖，抑制去甲肾上腺素，同时引起多巴胺的释放。这种相互关系，加上它们不同的时间进程，可以提供相反的享乐状态的整合，以影响适合生存的反应输出。
Traditionally, norepinephrine has been associated with stress responses while dopamine has been associated with reward. Both of these catecholamines are found within the bed nucleus of the stria terminalis (BNST), a brain relay nucleus in the extended amygdala between cortical/limbic centers, and the hypothalamic-pituitary-adrenal axis. Despite this colocalization, little is known about subsecond catecholamine signaling in subregions of the BNST in response to salient stimuli. Changes in extracellular catecholamine concentration in subregions of the BNST in response to salient stimuli were measured within the rat BNST using fast-scan cyclic voltammetry at carbon-fiber microelectrodes. A discrete subregional distribution of release events was observed for different catecholamines in this nucleus. In addition, rewarding and aversive tastants evoked inverse patterns of norepinephrine and dopamine release in the BNST. An aversive stimulus, quinine, activated noradrenergic signaling but inhibited dopaminergic signaling, while a palatable stimulus, sucrose, inhibited norepinephrine while causing dopamine release. This reciprocal relationship, coupled with their different time courses, can provide integration of opposing hedonic states to influence response outputs appropriate for survival.
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影响因子：
5
作者：
Keithley, Richard B.;Wightman, R. Mark
通讯作者：
Wightman, R. Mark
在大鼠和人类中持续的恐惧：恐惧与焦虑中的杏仁核的作用。
DOI：
10.1038/npp.2009.109
发表时间：
2010-01
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
10.6
作者：
Koob, GF
通讯作者：
Koob, GF
影响因子：
4.2
作者：
Heien, MLAV;Phillips, PEM;Wightman, RM
通讯作者：
Wightman, RM
影响因子：
5.3
作者：
Dumont, ÉC;Williams, JT
通讯作者：
Williams, JT