MiR-362-5p as a novel prognostic predictor of cytogenetically normal acute myeloid leukemia.
MiR-362-5p as a novel prognostic predictor of cytogenetically normal acute myeloid leukemia.
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MiR-362-5p 作为细胞遗传学正常急性髓系白血病的新型预后预测因子
DOI：
10.1186/s12967-018-1445-3
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发表时间：
2018-03-14
影响因子：
7.4
通讯作者：
Jin J
中科院分区：
文献类型：
--
作者：
Ma QL;Wang JH;Yang M;Wang HP;Jin J
MicroRNAs在癌症研究中具有特殊的意义，并作为恶性疾病的诊断和预后生物标记物具有重要的前景。已经发现，MIR-362-5P既有致癌作用，又有肿瘤抑制作用，这在很大程度上取决于细胞环境。本研究的目的是探讨miR-362-5p的表达能否作为细胞遗传学正常的急性髓系白血病(CN-AML)患者的预后指标。我们招募了224例CN-AML患者，用实时定量聚合酶链式反应检测miR-362-5p的表达。我们根据中位数将患者分为高表达和低表达。用Cox回归分析来评估miR-362-5p表达在已有的预测因素中的预后意义。此外，还进行了microRNA表达谱分析，以确定高分组和低分组之间的生物学洞察力。高发人群的年龄较大。在单变量分析中，高血压者的总体生存时间较短。MiR-362-5p的独立预后价值仍然存在于公认的临床和细胞遗传学预测因素的背景下。此外，miR-362-5p在CN-AML的独立队列中的预后价值也得到了验证。值得注意的是，在miR-362-5p高表达组中也有大量的癌基因高表达。MiR-362-5p的高表达与较差的总生存期相关，暗示了致癌作用在AML的发展中的作用。
MicroRNAs are of special interest in cancer research and hold significant promise as diagnostic and prognostic biomarkers for malignant disease. MiR-362-5p have been found to exert both oncogenic and tumor suppressive effects depending highly on the cellular context. The aim of this study was to determine whether the expression of miR-362-5p can be served as a prognostic factor for patients with cytogentically normal acute myeloid leukemia (CN-AML). We enrolled 224 patients with CN-AML and measured the expression of miR-362-5p by quantitative real time PCR analysis. We classified patients into high and low expression based on the median value. The Cox regression analyses were carried out to assess the prognostic significance of miR-362-5p expression in the context of the well-established predictors. Additionally, microRNA expression profiling were conducted to identify the biological insights between high and low group. High expressers had older age. High expressers obtained shorter overall survival in the univariate analysis. The independent prognostic value of miR-362-5p remained in the context of the well-established clinical and cytogenetic predictors. Moreover, the prognostic value of miR-362-5p was also validated in an independent cohort of CN-AML. Notably, numerous oncomiRs were also high expressed in high miR-362-5p group. High miR-362-5p expression was associated with poorer overall survival implicating the oncogenic function in AML development.
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影响因子：
28.5
作者：
Pastore F;Kling D;Hoster E;Dufour A;Konstandin NP;Schneider S;Sauerland MC;Berdel WE;Buechner T;Woermann B;Braess J;Hiddemann W;Spiekermann K
通讯作者：
Spiekermann K
影响因子：
11.4
作者：
Beillard, E;Pallisgaard, N;Gabert, J
通讯作者：
Gabert, J
microRNA 在翻译调控和癌症中的作用。
DOI：
10.4331/wjbc.v8.i1.45
发表时间：
2017-02-26
期刊：
World journal of biological chemistry
影响因子：
--
作者：
Oliveto S;Mancino M;Manfrini N;Biffo S
通讯作者：
Biffo S
DOI：
10.3109/10409238.2015.1117054
发表时间：
2016-05
影响因子：
6.5
作者：
Hata A;Kashima R
通讯作者：
Kashima R
影响因子：
2.6
作者：
Macfarlane LA;Murphy PR
通讯作者：
Murphy PR