Divergent relationship of circulating CTRP3 levels between obesity and gender: a cross-sectional study.
Divergent relationship of circulating CTRP3 levels between obesity and gender: a cross-sectional study.
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作者：
Wagner RM;Sivagnanam K;Clark WA;Peterson JM
C1q肿瘤坏死因子相关蛋白3(CTRP3)是一种新的脂肪组织源性分泌因子或脂肪因子，在多种组织中对新陈代谢、炎症和生存信号具有许多有益的生物学效应。然而，人们对CTRP3与人类健康的关系知之甚少。该项目的目的是检测临床人群中循环CTRP3的水平，这些患者的症状需要进行心脏插管，以确定是否存在阻塞性冠状动脉疾病(CAD)。据推测，冠心病患者的血清CTRP3水平会降低。体重指数(BMI)、糖尿病状况和血浆样本来自东田纳西州立大学心脏诊所的100名30岁的患者，他们的症状需要进行心脏插管以确定是否存在心血管阻塞(n=52名男性，n=48名女性)。循环CTRP3水平用商品化的酶联免疫吸附试验进行定量。循环CTRP3水平与冠心病的存在无关，无论性别。然而，正常体重(BMI<；30)女性(0.88±0.12微克/毫升)显著高于男性(0.54±0.06微克/毫升)。此外，肥胖(BMI和GT；30)导致男性受试者循环CTRP3水平增加(0.74±0.08微克/毫升)，而女性受试者显著下降(0.58±0.07微克/毫升)。此外，与非2型糖尿病患者相比，确诊为2型糖尿病的女性受试者的循环CTRP3水平显著降低(0.79±0.08比0.42±0.10微克/毫升)。男性受试者的糖尿病状况与循环CTRP3水平无关。男性和女性患者循环CTRP3水平与糖尿病和肥胖状况的关系不同。循环中的CTRP3水平可能受激素状态的控制，然而，需要更多的研究来探索这种关系。然而，未来研究CTRP3水平和疾病状况之间的关系时，应该把性别作为一个独立变量。
C1q TNF Related Protein 3 (CTRP3) is a novel adipose tissue derived secreted factor, or adipokine, which has been linked to a number of beneficial biological effects on metabolism, inflammation, and survival signaling in a variety of tissues. However, very little is known about CTRP3 in regards to human health. The purpose of this project was to examine circulating CTRP3 levels in a clinical population, patients with symptoms requiring heart catheterization in order to identify the presence of obstructive coronary artery disease (CAD). It was hypothesized that serum CTRP3 levels would be decreased in the presence of CAD. Body mass index (BMI), diabetes status, and plasma samples were collected from 100 patients who were >30 years of age and presented at the East Tennessee State University Heart Clinic with symptoms requiring heart catheterization in order to identify the presence of cardiovascular blockages (n = 52 male, n = 48 female). Circulating CTRP3 levels were quantified using commercially available ELISA. Circulating CTRP3 levels had no relationship to the presence of CAD regardless of gender. However, circulating concentrations of CTRP3 were significantly higher in normal weight (BMI < 30) females (0.88 ± 0.12 µg/ml) compared with males (0.54 ± 0.06 µg/ml). Further, obesity (BMI > 30) resulted in an increase in circulating CTRP3 levels in male subjects (0.74 ± 0.08 µg/ml) but showed a significant decrease in female subjects (0.58 ± 0.07 µg/ml). Additionally, there was a significant reduction in circulating CTRP3 levels in female subjects who were diagnosed with Type 2 diabetes compared with patients without (0.79 ± 0.08 vs. 0.42 ± 0.10 µg/ml). There was no relationship between diabetes status and circulating CTRP3 levels in male subjects. Circulating CTRP3 levels had a different relationship with diabetes and obesity status between male and female patients. It is possible that circulating CTRP3 levels are controlled by hormonal status, however more research is needed to explore this relationship. Nevertheless, future studies examining the relationship between CTRP3 levels and disease status should treat gender as an independent variable.
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影响因子：
4.8
作者：
Wei, Zhikui;Peterson, Jonathan M.;Wong, G. William
通讯作者：
Wong, G. William
DOI：
10.1073/pnas.0403760101
发表时间：
2004-07-13
影响因子：
11.1
作者：
Wong, GW;Wang, J;Lodish, HF
通讯作者：
Lodish, HF
中国肥胖和II型糖尿病患者血浆CTRP-3浓度与胰岛素抵抗呈负相关
影响因子：
4.4
作者：
Qu, Hua;Deng, Min;Deng, Huacong
通讯作者：
Deng, Huacong
影响因子：
4.8
作者：
Deng W;Li C;Zhang Y;Zhao J;Yang M;Tian M;Li L;Zheng Y;Chen B;Yang G
通讯作者：
Yang G
影响因子：
3.7
作者：
Wolf RM;Steele KE;Peterson LA;Magnuson TH;Schweitzer MA;Wong GW
通讯作者：
Wong GW