Serum C1q/TNF-related protein-3 (CTRP3) levels are decreased in obesity and hypertension and are negatively correlated with parameters of insulin resistance.
Serum C1q/TNF-related protein-3 (CTRP3) levels are decreased in obesity and hypertension and are negatively correlated with parameters of insulin resistance.
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DOI：
10.1186/s13098-015-0029-0
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发表时间：
2015
影响因子：
4.8
通讯作者：
Yang G
中科院分区：
文献类型：
--
作者：
Deng W;Li C;Zhang Y;Zhao J;Yang M;Tian M;Li L;Zheng Y;Chen B;Yang G
胰岛素抵抗（IR）与心血管疾病密切相关。C1 q/TNF相关蛋白3（C1 q/TNF-related protein-3，CTRP 3）是一种新的脂肪因子，在多种疾病中调节胰岛素活性。本研究调查了新诊断的肥胖和高血压患者中CTRP 3与IR以及全身炎症之间的关系（NCT 02226471）。测定了180例肥胖和原发性高血压患者和66例正常体重、血压正常的受试者的血清CTRP 3水平、人体测量、炎症和代谢参数。肥胖组的血清CTRP 3水平低于NW组;高血压受试者的血清CTRP 3水平也低于血压正常受试者。在调整性别、收缩压（SBP）和舒张压（DBP）后，观察到CTRP 3与腰围（WC）之间存在中度线性关系。（r =-0.168，p = 0.009），腰臀比（WHR）（r =-0.183，p = 0.004），IR的稳态模型评估（HOMA-IR）（r =-0.264，p = 0.000），甘油三酯（TG）（r =-0.136，p = 0.034），空腹血糖（FBG）（r =-0.155，p = 0.016），空腹胰岛素（FINS）（r =-0.248，p = 0.000）和β细胞胰岛素分泌（HOMA-β）的稳态模型评估（r =-0.128，p = 0.047）。多元逐步回归分析显示性别、DBP和HOMA-IR与血清CTRP 3水平独立相关。CTRP 3是影响血压和IR的独立因素，可能在肥胖和高血压的发病中起重要作用。
Insulin resistance (IR) correlates closely with cardiovascular disease. C1q/TNF-related protein-3 (CTRP3) is a novel adipokine that modulates insulin activity in various diseases. This study investigated the relationship between CTRP3 and IR as well as systemic inflammation in newly diagnosed obese and hypertensive patients (NCT02226471). Serum CTRP3 levels, anthropometric, inflammatory and metabolic parameters were measured in 180 obesity and essential hypertensive patients and in 66 normal weight, normotensive subjects. The serum CTRP3 levels in the obesity group were lower than those in the NW group; these levels were also lower in hypertensive subjects than in normotensive subjects. After adjusting for gender, systolic blood pressure (SBP) and diastolic blood pressure (DBP), a modestly linear relationship was observed between CTRP3 and waist circumference (WC) (r = -0.168, p = 0.009), waist-to-hip ratio (WHR) (r = -0.183, p = 0.004), homeostasis model assessment of IR (HOMA-IR) (r = -0.264, p = 0.000), triglycerides (TG) (r = -0.136, p = 0.034), fasting blood glucose (FBG) (r = -0.155, p = 0.016), fasting insulin (FINS) (r = -0.248, p = 0.000) and homeostasis model assessment of β-cell insulin secretion (HOMA-β) (r = -0.128, p = 0.047). Multiple stepwise regression analysis revealed that gender, DBP and HOMA-IR were independently associated with serum CTRP3 levels. CTRP3 was an independent factor affecting blood pressure and IR, and may play an important role in the pathogenesis of obesity and hypertension.
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影响因子：
16.2
作者：
Freiberg, MS;Cabral, HJ;Ellison, RC
通讯作者：
Ellison, RC
影响因子：
2.7
作者：
Phillips, A. C.;Jiang, C. Q.;Lam, T. H.
通讯作者：
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影响因子：
9.3
作者：
Wurm S;Neumeier M;Weigert J;Schäffler A;Buechler C
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Buechler C
影响因子：
3.2
作者：
Wen, Chi Pang;Cheng, Ting Yuan David;Eriksen, Michael P.
通讯作者：
Eriksen, Michael P.
影响因子：
3.9
作者：
Maeda, Takashi;Wakisaka, Satoshi
通讯作者：
Wakisaka, Satoshi