Neurocognitive efficiency in breast cancer survivorship: A performance monitoring ERP study.
Neurocognitive efficiency in breast cancer survivorship: A performance monitoring ERP study.
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DOI：
10.1016/j.ijpsycho.2021.06.013
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发表时间：
2021-10
影响因子：
3
通讯作者：
Derakshan, Nazanin
中科院分区：
文献类型：
--
作者：
Swainston, Jessica;Louis, Courtney;Moser, Jason;Derakshan, Nazanin
乳腺癌的诊断和治疗可能导致长期的认知和情感脆弱性，使有效适应挫折的能力变得至关重要。虽然乳腺癌幸存者中经常报告癌症相关的认知障碍（CRCI），但对有效处理错误的能力的调查有限。本研究探讨了认知控制相关的绩效监控，影响行为调整的一个重要功能，以错误的神经认知相关。62名参与者（30名乳腺癌幸存者，32名非癌症患者）完成了一项改良的侧翼任务，旨在挑战反应抑制，因为我们测量了表现监测的神经认知指标（ERN，错误相关负性; CRN，正确反应负性; Pe，错误正性）。结果表明，在没有性能影响的情况下，与非癌症组相比，乳腺癌幸存者的CRN变钝，ΔERN更大。其次是乳腺癌幸存者组的Pe更大，表明夸大的性能监测反应。对于受乳腺癌影响的女性，研究结果表明，早期中断的神经反应，以监测认知性能，其次是需要更努力的处理有意识的反应错误，表明神经认知效率的赤字。这些研究结果具有重要的意义，为乳腺癌幸存者的认知功能障碍，以协助监测和调整所需的性能，以满足既定的目标，在面对逆境的认知康复计划。
Breast cancer diagnosis and treatment can lead to longer term cognitive and emotional vulnerability, making the ability to efficiently adapt to setbacks critical. Whilst cancer-related cognitive impairments (CRCI) are often reported amongst breast cancer survivors, investigation into the capacity to efficiently process errors is limited. The present study investigated the neurocognitive correlates of cognitive-control related performance monitoring, an important function influencing behavioural adjustment to mistakes. 62 participants (30 Breast Cancer Survivors, 32 Non-Cancer) completed a modified flanker task designed to challenge response inhibition as we measured neurocognitive indices of performance monitoring (ERN, the error-related negativity; CRN, the correct-response negativity; Pe, the error positivity). Findings indicated a blunted CRN and larger ΔERN in the breast cancer survivors compared to the non-cancer group, in the absence of performance effects. This was followed by a larger Pe in the breast cancer survivors' group, indicating an exaggerated performance monitoring response. For women affected by breast cancer, findings suggest an early disrupted neural response to monitoring cognitive performance, followed by the requirement for more effortful processing in the conscious response to errors, indicating deficits in neurocognitive efficiency. These findings have important implications for developing cognitive rehabilitation programmes for breast cancer survivors affected by cognitive dysfunction to assist in the monitoring and adjustment of performance required to meet established goals in the face of adversity.
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