Sex differences in pharmacokinetics and pharmacodynamics.
Sex differences in pharmacokinetics and pharmacodynamics.
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DOI:
10.2165/00003088-200948030-00001
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发表时间:
2009
影响因子:
4.5
通讯作者:
Mattison DR
中科院分区:
文献类型:
--
作者:
Soldin OP;Mattison DR
Males and females differ in their response to drug treatment. These differences can be critical in response to drug treatment. It is therefore essential to understand those differences to appropriately conduct risk assessment and to design safe and effective treatments. Even from that modest perspective, how and when we use drugs can result in unwanted and unexpected outcomes. We summarize the sex differences that impact pharmacokinetics and pharmacodynamics and include a general comparison of clinical pharmacology as it applies to men, pregnant and non-pregnant women. Since this is an area rapidly evolving, it is essential for the practitioner to review drug prescribing information and recent literature to understand fully the impact of sex differences in clinical therapeutics.
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