Sex differences in pharmacokinetics and pharmacodynamics.

Sex differences in pharmacokinetics and pharmacodynamics.
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DOI:
10.2165/00003088-200948030-00001
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发表时间:
2009
影响因子:
4.5
通讯作者:
Mattison DR
Mattison DR
中科院分区:
医学2区
文献类型:
--
作者:
Soldin OP;Mattison DR

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男性和女性对药物治疗的反应有所不同。这些差异对于响应药物治疗至关重要。因此,必须了解这些差异,以进行适当的风险评估并设计安全有效的治疗方法。即使从这个谦虚的角度来看,我们如何以及何时使用药物也会导致不必要的意外结果。我们总结了影响药代动力学和药效动力学的性别差异,并包括适用于男性,孕妇和非怀孕妇女的临床药理学的一般比较。由于这是一个迅速发展的领域,因此,从业者必须审查药物处方信息和最近的文献,以便完全了解性别差异在临床治疗中的影响。
Males and females differ in their response to drug treatment. These differences can be critical in response to drug treatment. It is therefore essential to understand those differences to appropriately conduct risk assessment and to design safe and effective treatments. Even from that modest perspective, how and when we use drugs can result in unwanted and unexpected outcomes. We summarize the sex differences that impact pharmacokinetics and pharmacodynamics and include a general comparison of clinical pharmacology as it applies to men, pregnant and non-pregnant women. Since this is an area rapidly evolving, it is essential for the practitioner to review drug prescribing information and recent literature to understand fully the impact of sex differences in clinical therapeutics.
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