CDD: a Conserved Domain Database for the functional annotation of proteins.
CDD: a Conserved Domain Database for the functional annotation of proteins.
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DOI：
10.1093/nar/gkq1189
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发表时间：
2011-01
影响因子：
14.9
通讯作者：
Bryant SH
中科院分区：
文献类型：
--
作者：
Marchler-Bauer A;Lu S;Anderson JB;Chitsaz F;Derbyshire MK;DeWeese-Scott C;Fong JH;Geer LY;Geer RC;Gonzales NR;Gwadz M;Hurwitz DI;Jackson JD;Ke Z;Lanczycki CJ;Lu F;Marchler GH;Mullokandov M;Omelchenko MV;Robertson CL;Song JS;Thanki N;Yamashita RA;Zhang D;Zhang N;Zheng C;Bryant SH
NCBI的保守结构域数据库（CDD）是一个资源，用于注释蛋白质序列的保守结构域足迹的位置，并从这些足迹推断的功能位点。CDD包括手动策划的结构域模型，该模型利用蛋白质3D结构来细化结构域模型并提供对序列/结构/功能关系的见解。如果手动策划的模型描述的领域家族通过共同的血统而明显相关，则它们是分层组织的。由于CDD还从各种外部源导入域族模型，因此它是一个部分冗余的集合。为了简化蛋白质注释，冗余模型和描述同源家族的模型被聚类成超家族。默认情况下，域足迹用相应的超家族名称进行注释，在此之上，特定的注释可以指示家族成员的高置信度分配。预先计算的结构域注释可用于蛋白质数据集中的蛋白质，一个新的界面，批量CD搜索，允许计算和下载大量蛋白质查询的注释。CDD可以通过http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml访问。
NCBI’s Conserved Domain Database (CDD) is a resource for the annotation of protein sequences with the location of conserved domain footprints, and functional sites inferred from these footprints. CDD includes manually curated domain models that make use of protein 3D structure to refine domain models and provide insights into sequence/structure/function relationships. Manually curated models are organized hierarchically if they describe domain families that are clearly related by common descent. As CDD also imports domain family models from a variety of external sources, it is a partially redundant collection. To simplify protein annotation, redundant models and models describing homologous families are clustered into superfamilies. By default, domain footprints are annotated with the corresponding superfamily designation, on top of which specific annotation may indicate high-confidence assignment of family membership. Pre-computed domain annotation is available for proteins in the Entrez/Protein dataset, and a novel interface, Batch CD-Search, allows the computation and download of annotation for large sets of protein queries. CDD can be accessed via http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml.
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影响因子：
14.9
作者：
Marchler-Bauer A;Anderson JB;Chitsaz F;Derbyshire MK;DeWeese-Scott C;Fong JH;Geer LY;Geer RC;Gonzales NR;Gwadz M;He S;Hurwitz DI;Jackson JD;Ke Z;Lanczycki CJ;Liebert CA;Liu C;Lu F;Lu S;Marchler GH;Mullokandov M;Song JS;Tasneem A;Thanki N;Yamashita RA;Zhang D;Zhang N;Bryant SH
通讯作者：
Bryant SH
影响因子：
14.9
作者：
Finn RD;Mistry J;Tate J;Coggill P;Heger A;Pollington JE;Gavin OL;Gunasekaran P;Ceric G;Forslund K;Holm L;Sonnhammer EL;Eddy SR;Bateman A
通讯作者：
Bateman A
影响因子：
14.9
作者：
Marchler-Bauer, A;Bryant, SH
通讯作者：
Bryant, SH
影响因子：
14.9
作者：
Sayers EW;Barrett T;Benson DA;Bolton E;Bryant SH;Canese K;Chetvernin V;Church DM;Dicuccio M;Federhen S;Feolo M;Geer LY;Helmberg W;Kapustin Y;Landsman D;Lipman DJ;Lu Z;Madden TL;Madej T;Maglott DR;Marchler-Bauer A;Miller V;Mizrachi I;Ostell J;Panchenko A;Pruitt KD;Schuler GD;Sequeira E;Sherry ST;Shumway M;Sirotkin K;Slotta D;Souvorov A;Starchenko G;Tatusova TA;Wagner L;Wang Y;John Wilbur W;Yaschenko E;Ye J
通讯作者：
Ye J
影响因子：
1.8
作者：
Fong, Jessica H;Marchler-Bauer, Aron
通讯作者：
Marchler-Bauer, Aron