Nongenetic Determinants of Risk for Early-Onset Colorectal Cancer.
Nongenetic Determinants of Risk for Early-Onset Colorectal Cancer.
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早发性结直肠癌风险的非遗传决定因素。
DOI：
10.1093/jncics/pkab029
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发表时间：
2021-06
影响因子：
4.4
通讯作者：
Hayes RB
中科院分区：
文献类型：
--
作者：
Archambault AN;Lin Y;Jeon J;Harrison TA;Bishop DT;Brenner H;Casey G;Chan AT;Chang-Claude J;Figueiredo JC;Gallinger S;Gruber SB;Gunter MJ;Hoffmeister M;Jenkins MA;Keku TO;Marchand LL;Li L;Moreno V;Newcomb PA;Pai R;Parfrey PS;Rennert G;Sakoda LC;Sandler RS;Slattery ML;Song M;Win AK;Woods MO;Murphy N;Campbell PT;Su YR;Zeleniuch-Jacquotte A;Liang PS;Du M;Hsu L;Peters U;Hayes RB
在许多国家，早发性（小于50岁）结直肠癌（CRC）的发病率正在增加。因此，阐明传统的CRC风险因素在早发性CRC中的作用是一个高度优先事项。我们试图确定与晚发性结直肠癌相关的危险因素是否也与早发性结直肠癌相关，以及相关模式是否因解剖部位而异。使用13项基于人群的研究的汇总数据，我们研究了年龄小于50岁的3767例CRC病例和4049例对照，以及年龄大于50岁的23437例CRC病例和35311例对照。使用多变量和多项逻辑回归，我们估计了比值比（OR）和95%置信区间（CI），以评估危险因素与早发性结直肠癌之间的相关性，并按解剖学亚部位进行评估。早发性结直肠癌与非甾体类抗炎药的不规律使用有关（OR = 1.43，95% CI = 1.21至1.68），红肉摄入量增加（OR = 1.10，95%CI = 1.04 ~ 1.16），文化程度低（OR = 1.10，95% CI = 1.04 ~ 1.16）、戒酒（OR = 1.23，95% CI = 1.08 ~ 1.39）和大量饮酒（OR = 1.25，95% CI = 1.04 ~ 1.50）。与晚发性CRC相比，早发性CRC中没有任何因素表现出更大的过量。通过解剖亚部位评估风险，我们发现总纤维摄入量较低与直肠癌（OR = 1.30，95%CI = 1.14至1.48）的关系比结肠癌（OR = 1.14，95%CI = 1.02至1.27; P = 0.04）更密切。在这项大型研究中，我们确定了与早发性CRC相关的几个非遗传性风险因素，为有针对性地识别风险最高的人群提供了基础，这对于减轻这种疾病日益增加的负担至关重要。
Incidence of early-onset (younger than 50 years of age) colorectal cancer (CRC) is increasing in many countries. Thus, elucidating the role of traditional CRC risk factors in early-onset CRC is a high priority. We sought to determine whether risk factors associated with late-onset CRC were also linked to early-onset CRC and whether association patterns differed by anatomic subsite. Using data pooled from 13 population-based studies, we studied 3767 CRC cases and 4049 controls aged younger than 50 years and 23 437 CRC cases and 35 311 controls aged 50 years and older. Using multivariable and multinomial logistic regression, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) to assess the association between risk factors and early-onset CRC and by anatomic subsite. Early-onset CRC was associated with not regularly using nonsteroidal anti-inflammatory drugs (OR = 1.43, 95% CI = 1.21 to 1.68), greater red meat intake (OR = 1.10, 95% CI = 1.04 to 1.16), lower educational attainment (OR = 1.10, 95% CI = 1.04 to 1.16), alcohol abstinence (OR = 1.23, 95% CI = 1.08 to 1.39), and heavier alcohol use (OR = 1.25, 95% CI = 1.04 to 1.50). No factors exhibited a greater excess in early-onset compared with late-onset CRC. Evaluating risks by anatomic subsite, we found that lower total fiber intake was linked more strongly to rectal (OR = 1.30, 95% CI = 1.14 to 1.48) than colon cancer (OR = 1.14, 95% CI = 1.02 to 1.27; P = .04). In this large study, we identified several nongenetic risk factors associated with early-onset CRC, providing a basis for targeted identification of those most at risk, which is imperative in mitigating the rising burden of this disease.
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影响因子：
16.9
作者：
Bailey CE;Hu CY;You YN;Bednarski BK;Rodriguez-Bigas MA;Skibber JM;Cantor SB;Chang GJ
通讯作者：
Chang GJ
影响因子：
29.4
作者：
Archambault, Alexi N.;Su, Yu-Ru;Hayes, Richard B.
通讯作者：
Hayes, Richard B.
影响因子：
2.8
作者：
Gutlic, Ida;Schyman, Tommy;Buchwald, Pamela
通讯作者：
Buchwald, Pamela
影响因子：
12.7
作者：
Hu, Frank B.;Satija, Ambika;Willett, Walter C.
通讯作者：
Willett, Walter C.
影响因子：
28.4
作者：
Liu, Po-Hong;Wu, Kana;Cao, Yin
通讯作者：
Cao, Yin