Rapid coordination of effective learning by the human hippocampus.

Rapid coordination of effective learning by the human hippocampus.
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人类海马有效学习的快速协调。

DOI:
10.1126/sciadv.abf7144
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发表时间:
2021-06
期刊:
影响因子:
13.6
通讯作者:
Voss JL
Voss JL
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Kragel JE;Schuele S;VanHaerents S;Rosenow JM;Voss JL

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人类大脑的直接记录揭示了记忆如何快速引导视觉来支持学习。虽然人类的海马体对于长期记忆是必需的,但有争议的发现表明,它也可能支持短期记忆,以指导学习过程中的有效行为。我们测试了一种违反直觉的理论,即海马体通过显著的短期处理促进长期记忆,这反映在场景编码过程中的眼球运动中。在第一次观看场景时,一种特定的眼动模式表明,短时提取在情节中仅持续数百毫秒,这是有效的,因为它增强了时空记忆的形成。这种观察模式是通过从深度电极记录的海马theta振荡以及通过海马theta对视觉感知和注意网络中的活动的自上而下的影响来预测的。因此,海马体支持协调行为的短期记忆处理,以服务于有效的时空学习。
Direct human brain recordings reveal how memory rapidly directs vision to support learning. Although the human hippocampus is necessary for long-term memory, controversial findings suggest that it may also support short-term memory in the service of guiding effective behaviors during learning. We tested the counterintuitive theory that the hippocampus contributes to long-term memory through remarkably short-term processing, as reflected in eye movements during scene encoding. While viewing scenes for the first time, short-term retrieval operative within the episode over only hundreds of milliseconds was indicated by a specific eye-movement pattern, which was effective in that it enhanced spatiotemporal memory formation. This viewing pattern was predicted by hippocampal theta oscillations recorded from depth electrodes and by shifts toward top-down influence of hippocampal theta on activity within visual perception and attention networks. The hippocampus thus supports short-term memory processing that coordinates behavior in the service of effective spatiotemporal learning.
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