Combat-related blast exposure and traumatic brain injury influence brain glucose metabolism during REM sleep in military veterans.
Combat-related blast exposure and traumatic brain injury influence brain glucose metabolism during REM sleep in military veterans.
复制标题
DOI：
10.1016/j.neuroimage.2014.05.067
复制
发表时间：
2014-10-01
期刊：
影响因子：
5.7
通讯作者：
Germain A
中科院分区：
文献类型：
--
作者：
Stocker RP;Cieply MA;Paul B;Khan H;Henry L;Kontos AP;Germain A
创伤性脑损伤（TBI），持久行动和伊拉克自由的标志性伤口，可能是由于头部钝伤或暴露于爆炸/爆炸。虽然TBI影响睡眠，但TBI和睡眠之间的神经生物学基础在很大程度上是未知的。为了研究退伍军人中这种关系的神经生物学基础，[18 F]-氟脱氧葡萄糖正电子发射断层扫描（FDG PET）被用来比较在调整创伤后应激（PTS）的影响后，清醒，快速眼动（REM）睡眠和非REM（NREM）睡眠期间相对脑葡萄糖代谢率（rCMRglc）的mTBI相关变化。14名有冲击波暴露史和/或mTBI（B/mTBI）（年龄27.5 ± 3.9）的退伍军人和11名无冲击波暴露史（无B/mTBI）（年龄27.7 ± 3.8）的退伍军人在觉醒、REM睡眠和NREM睡眠期间完成了FDG PET研究。使用统计参数映射（SPM 8）进行全脑分析。组间比较显示，B/mTBI与清醒和REM睡眠期间杏仁核、海马、海马旁回、丘脑、海马、钩回、峰、视觉关联皮质和中线内侧额叶皮质中显著较低的rCMRglc相关。这些结果表明，B/mTBI暴露后觉醒和REM睡眠期间神经生物学网络的改变可能导致慢性睡眠障碍，并且在具有急性症状的个体中有所不同。
Traumatic Brain Injury (TBI), a signature wound of Operations Enduring and Iraqi Freedom, can result from blunt head trauma or exposure to a blast/explosion. While TBI affects sleep, the neurobiological underpinnings between TBI and sleep are largely unknown. To examine the neurobiological underpinnings of this relationship in military veterans, [18F]-fluorodeoxyglucose positron emission tomography (FDG PET) was used to compare mTBI-related changes in relative cerebral metabolic rate of glucose (rCMRglc) during wakefulness, Rapid Eye Movement (REM) sleep, and non-REM (NREM) sleep, after adjusting for the effects of posttraumatic stress (PTS). Fourteen Veterans with a history of Blast Exposure and/or mTBI (B/mTBI) (age 27.5 ± 3.9) and eleven Veterans with no history (No B/mTBI) (age 27.7 ± 3.8) completed FDG PET studies during wakefulness, REM sleep, and NREM sleep. Whole-brain analyses were conducted using Statistical Parametric Mapping (SPM8). Between group comparisons revealed that B/mTBI was associated with significantly lower rCMRglc during wakefulness and REM sleep in the amygdala, hippocampus, parahippocampal gyrus, thalamus, insula, uncus, culmen, visual association cortices, and midline medial frontal cortices. These results suggest alterations in neurobiological networks during Wakefulness and REM sleep subsequent to B/mTBI exposure, may contribute to chronic sleep disturbances, and differ in individuals with acute symptoms.
登录
查看更多内容
在大鼠和人类中持续的恐惧：恐惧与焦虑中的杏仁核的作用。
DOI：
10.1038/npp.2009.109
发表时间：
2010-01
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.1
作者：
Creamer, M;O'Donnell, ML;Pattison, P
通讯作者：
Pattison, P
影响因子：
7.6
作者：
Edison, Paul;Ahmed, Imtiaz;Brooks, David J.
通讯作者：
Brooks, David J.
DOI：
10.1017/s1355617709990798
发表时间：
2010-01-01
影响因子：
2.6
作者：
Bloomfield, Imogen L. M.;Espie, Colin A.;Evans, Jonathan J.
通讯作者：
Evans, Jonathan J.
影响因子：
11.3
作者：
BUYSSE, DJ;REYNOLDS, CF;KUPFER, DJ
通讯作者：
KUPFER, DJ