Topical carbonic anhydrase inhibitors and glaucoma in 2021: where do we stand?
Topical carbonic anhydrase inhibitors and glaucoma in 2021: where do we stand?
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DOI：
10.1136/bjophthalmol-2021-319530
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发表时间：
2022-10
期刊：
影响因子：
--
通讯作者：
Siesky B
中科院分区：
文献类型：
--
作者：
Stoner A;Harris A;Oddone F;Belamkar A;Verticchio Vercellin AC;Shin J;Januleviciene I;Siesky B
碳酸酐酶抑制剂(CAI)用于青光眼的治疗已有几十年的历史。全身性CAI是通过减少房水体液产生来降低眼压的早期治疗选择；然而，包括多尿和感觉异常在内的频繁副作用导致了局部CAI的最终发展。随着局部药物开发随着时间的推移而发展，前列腺素类似物和β-受体阻滞剂已经成为青光眼治疗的黄金标准。尽管与其他类别的局部青光眼疗法相比，局部CAI的处方较少，但局部CAI仍继续用于与β-受体阻滞剂和α-激动剂的联合治疗。局部CAI也被证明可以改变眼血流动力学的生物标记物，这与青光眼有关。本综述的目的是回顾和总结局部用药治疗青光眼的发展趋势、已知的疗效、机制和对眼血流动力学的潜在影响。
Carbonic anhydrase inhibitors (CAIs) have been used for many decades in the treatment of glaucoma. Systemic CAIs were an early treatment option to lower intraocular pressure by reducing aqueous humour production; however, frequent side effects including polyuria and paresthesia contributed to the eventual development of topical CAIs. As topical drug development evolved over time, prostaglandin analogues and beta-blockers have become the gold standard of glaucoma therapies. Although prescribed less often than other classes of topical glaucoma therapies, topical CAIs continue to be used in combination therapies with beta-blockers and alpha agonists. Topical CAIs have also been demonstrated to alter biomarkers of ocular haemodynamics, which have relevance in glaucoma. The purpose of this review is to review and summarise the current state of topical CAI prescribing trends, known efficacy and suggested mechanisms and potential influence on ocular haemodynamics for the future of glaucoma management.
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影响因子：
13.7
作者：
Harris, A;Arend, O;Martin, B
通讯作者：
Martin, B
影响因子：
3.9
作者：
Fechtner, R. D.;Myers, J. S.;Hubatsch, D. A.;Budenz, D. L.;DuBiner, H. B.
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DuBiner, H. B.
影响因子：
7.3
作者：
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通讯作者：
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影响因子：
4.1
作者：
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Schmetterer, L
影响因子：
8.3
作者：
Dallinger, S;Bobr, B;Schmetterer, L
通讯作者：
Schmetterer, L