Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years.
Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years.
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DOI：
10.1002/hbm.25320
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发表时间：
2022-01
影响因子：
4.8
通讯作者：
Karolinska Schizophrenia Project (KaSP)
中科院分区：
文献类型：
--
作者：
Dima D;Modabbernia A;Papachristou E;Doucet GE;Agartz I;Aghajani M;Akudjedu TN;Albajes-Eizagirre A;Alnaes D;Alpert KI;Andersson M;Andreasen NC;Andreassen OA;Asherson P;Banaschewski T;Bargallo N;Baumeister S;Baur-Streubel R;Bertolino A;Bonvino A;Boomsma DI;Borgwardt S;Bourque J;Brandeis D;Breier A;Brodaty H;Brouwer RM;Buitelaar JK;Busatto GF;Buckner RL;Calhoun V;Canales-Rodríguez EJ;Cannon DM;Caseras X;Castellanos FX;Cervenka S;Chaim-Avancini TM;Ching CRK;Chubar V;Clark VP;Conrod P;Conzelmann A;Crespo-Facorro B;Crivello F;Crone EA;Dannlowski U;Dale AM;Davey C;de Geus EJC;de Haan L;de Zubicaray GI;den Braber A;Dickie EW;Di Giorgio A;Doan NT;Dørum ES;Ehrlich S;Erk S;Espeseth T;Fatouros-Bergman H;Fisher SE;Fouche JP;Franke B;Frodl T;Fuentes-Claramonte P;Glahn DC;Gotlib IH;Grabe HJ;Grimm O;Groenewold NA;Grotegerd D;Gruber O;Gruner P;Gur RE;Gur RC;Hahn T;Harrison BJ;Hartman CA;Hatton SN;Heinz A;Heslenfeld DJ;Hibar DP;Hickie IB;Ho BC;Hoekstra PJ;Hohmann S;Holmes AJ;Hoogman M;Hosten N;Howells FM;Hulshoff Pol HE;Huyser C;Jahanshad N;James A;Jernigan TL;Jiang J;Jönsson EG;Joska JA;Kahn R;Kalnin A;Kanai R;Klein M;Klyushnik TP;Koenders L;Koops S;Krämer B;Kuntsi J;Lagopoulos J;Lázaro L;Lebedeva I;Lee WH;Lesch KP;Lochner C;Machielsen MWJ;Maingault S;Martin NG;Martínez-Zalacaín I;Mataix-Cols D;Mazoyer B;McDonald C;McDonald BC;McIntosh AM;McMahon KL;McPhilemy G;Meinert S;Menchón JM;Medland SE;Meyer-Lindenberg A;Naaijen J;Najt P;Nakao T;Nordvik JE;Nyberg L;Oosterlaan J;de la Foz VO;Paloyelis Y;Pauli P;Pergola G;Pomarol-Clotet E;Portella MJ;Potkin SG;Radua J;Reif A;Rinker DA;Roffman JL;Rosa PGP;Sacchet MD;Sachdev PS;Salvador R;Sánchez-Juan P;Sarró S;Satterthwaite TD;Saykin AJ;Serpa MH;Schmaal L;Schnell K;Schumann G;Sim K;Smoller JW;Sommer I;Soriano-Mas C;Stein DJ;Strike LT;Swagerman SC;Tamnes CK;Temmingh HS;Thomopoulos SI;Tomyshev AS;Tordesillas-Gutiérrez D;Trollor JN;Turner JA;Uhlmann A;van den Heuvel OA;van den Meer D;van der Wee NJA;van Haren NEM;Van't Ent D;van Erp TGM;Veer IM;Veltman DJ;Voineskos A;Völzke H;Walter H;Walton E;Wang L;Wang Y;Wassink TH;Weber B;Wen W;West JD;Westlye LT;Whalley H;Wierenga LM;Williams SCR;Wittfeld K;Wolf DH;Worker A;Wright MJ;Yang K;Yoncheva Y;Zanetti MV;Ziegler GC;Thompson PM;Frangou S;Karolinska Schizophrenia Project (KaSP)
年龄对脑容量有很大影响。然而，现有的规范性研究受到样本量小、年龄范围有限和方法学差异大的限制。这些限制引入了不一致性，并且可能模糊或扭曲脑形态测量的寿命轨迹。作为回应，我们利用通过Meta-分析增强神经影像遗传学（ENIGMA）联盟的资源，使用从18，605名3-90岁个体获得的磁共振成像数据，检查从脑室、基底神经节（尾状核、壳核、苍白球和丘脑核）、丘脑、海马和杏仁核的横截面测量推断的年龄相关轨迹。所有皮质下结构体积在生命早期达到最大值。此后，基底神经节的体积与年龄呈单调负相关;年龄与丘脑、杏仁核和海马（丘脑有一定程度的下降）的体积之间没有显著相关性，直到60岁，之后它们也与年龄呈陡峭的负相关性。侧脑室在整个生命周期内持续扩大。年龄与海马、杏仁核和侧脑室的个体间变异性呈正相关。这些结果对潜在混杂因素具有稳健性，可用于检查偏离典型年龄相关形态学模式的功能意义。我们分析了来自多个横断面队列的18，605名健康个体的皮质下体积，以推断3至90岁之间的年龄相关轨迹。
Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta‐Analysis (ENIGMA) Consortium to examine age‐related trajectories inferred from cross‐sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3–90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter‐individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age‐related morphometric patterns. We analyzed subcortical volumes from 18,605 healthy individuals from multiple cross‐sectional cohorts to infer age‐related trajectories between the ages of 3 and 90 years.
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影响因子：
11
作者：
Hibar, D. P.;Westlye, L. T.;van Erp, T. G. M.;Rasmussen, J.;Leonardo, C. D.;Faskowitz, J.;Haukvik, U. K.;Hartberg, C. B.;Doan, N. T.;Agartz, I.;Dale, A. M.;Gruber, O.;Kraemer, B.;Trost, S.;Liberg, B.;Abe, C.;Ekman, C. J.;Ingvar, M.;Landen, M.;Fears, S. C.;Freimer, N. B.;Bearden, C. E.;Sprooten, E.;Glahn, D. C.;Pearlson, G. D.;Emsell, L.;Kenney, J.;Scanlon, C.;McDonald, C.;Cannon, D. M.;Almeida, J.;Versace, A.;Caseras, X.;Lawrence, N. S.;Phillips, M. L.;Dima, D.;Delvecchio, G.;Frangou, S.;Satterthwaite, T. D.;Wolf, D.;Houenou, J.;Henry, C.;Malt, U. F.;Boen, E.;Elvsashagen, T.;Young, A. H.;Lloyd, A. J.;Goodwin, G. M.;Mackay, C. E.;Bourne, C.;Bilderbeck, A.;Abramovic, L.;Boks, M. P.;van Haren, N. E. M.;Ophoff, R. A.;Kahn, R. S.;Bauer, M.;Pfennig, A.;Alda, M.;Hajek, T.;Mwangi, B.;Soares, J. C.;Nickson, T.;Dimitrova, R.;Sussmann, J. E.;Hagenaars, S.;Whalley, H. C.;McIntosh, A. M.;Thompson, P. M.;Andreassen, O. A.
通讯作者：
Andreassen, O. A.
影响因子：
5.4
作者：
Keyes, Katherine M.;Utz, Rebecca L.;Robinson, Whitney;Li, Guohua
通讯作者：
Li, Guohua
DOI：
10.1098/rstb.2008.0307
发表时间：
2009-05-12
影响因子：
6.3
作者：
Grossberg, Stephen
通讯作者：
Grossberg, Stephen
影响因子：
2
作者：
COLE, TJ;GREEN, PJ
通讯作者：
GREEN, PJ
影响因子：
5.7
作者：
Pfefferbaum A;Rohlfing T;Rosenbloom MJ;Chu W;Colrain IM;Sullivan EV
通讯作者：
Sullivan EV