Variation in longitudinal trajectories of regional brain volumes of healthy men and women (ages 10 to 85 years) measured with atlas-based parcellation of MRI.
Variation in longitudinal trajectories of regional brain volumes of healthy men and women (ages 10 to 85 years) measured with atlas-based parcellation of MRI.
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DOI：
10.1016/j.neuroimage.2012.10.008
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发表时间：
2013-01-15
期刊：
影响因子：
5.7
通讯作者：
Sullivan EV
中科院分区：
文献类型：
--
作者：
Pfefferbaum A;Rohlfing T;Rosenbloom MJ;Chu W;Colrain IM;Sullivan EV
大量的横断面MRI研究表明，不同结构和组织类型的区域脑体积存在与年龄相关的差异。关于变化的横截面假设在多大程度上是对实际纵向测量的准确解释仍然存在争议。即使是纵向研究也会受到参与者年龄范围、样本性别分布和扫描间隔的限制。为了解决这些问题，我们从T1加权（SPGR）MRI数据中计算了局部脑体积变化的轨迹，并使用我们的自动化，无监督的SRI 24基于图谱的配准和分割方法进行了量化。在3 T纵向MRI中获得了17名男孩和12名女孩，年龄10至14岁，以及41名男性和41名女性，首次扫描时年龄20至85岁。基于回归的校正因子的应用允许将在3 T场强下采集的数据与在1.5T下从其他受试者采集的数据合并，从而将样本扩展到总共55名男性和67名女性，首次扫描时年龄为20至85岁。个体幕上颅内体积的调整消除了男性和女性之间由于头部大小的性别相关差异而导致的区域体积差异。根据在约1至8年时间间隔内以单一场强在2至6次MRI上收集的数据计算个体轨迹。使用线性混合效应模型，随年龄变化的轨迹模式表明：脑室和侧裂体积增加，老年人比年轻人增加更快;老年人比年轻人选择性皮质体积下降，组织收缩更快;年龄对胼胝体体积的影响很小; 60岁后男性CSF填充空间的扩张比女性更快;并有证据表明，在成年早期，中央白色物质持续增长，男性比女性衰老速度更快。
Numerous cross-sectional MRI studies have characterized age-related differences in regional brain volumes that differ with structure and tissue type. The extent to which cross-sectional assumptions about change are accurate depictions of actual longitudinal measurement remains controversial. Even longitudinal studies can be limited by the age range of participants, sex distribution of the samples, and scan intervals. To address these issues, we calculated trajectories of regional brain volume changes from T1-weighted (SPGR) MRI data, quantified with our automated, unsupervised SRI24 atlas-based registration and parcellation method. Longitudinal MRIs were acquired at 3T in 17 boys and 12 girls, age 10 to 14 years, and 41 men and 41 women, age 20 to 85 years at first scan. Application of a regression-based correction factor permitted merging of data acquired at 3T field strength with data acquired at 1.5T from additional subjects, thereby expanding the sample to a total of 55 men and 67 women, ages 20 to 85 years at first scan. Adjustment for individual supratentorial intracranial volume removed regional volume differences between men and women due to sex-related differences in head size. Individual trajectories were computed from data collected on 2 to 6 MRIs at a single field strength over a ~1 to 8 year interval. Using the linear mixed-effects model, the pattern of trajectories over age indicated: rises in ventricular and Sylvian fissure volumes, with older individuals showing faster increases than younger ones; declines in selective cortical volumes with faster tissue shrinkage in older than younger individuals; little effect of aging on volume of the corpus callosum; more rapid expansion of CSF-filled spaces in men than women after age 60 years; and evidence for continued growth in central white matter through early adulthood with accelerated decline in senescence greater in men than women.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
DOI：
10.1523/jneurosci.3252-09.2009
发表时间：
2009-12-02
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fjell AM;Walhovd KB;Fennema-Notestine C;McEvoy LK;Hagler DJ;Holland D;Brewer JB;Dale AM
通讯作者：
Dale AM
影响因子：
5.7
作者：
Fjell, Anders M.;Walhovd, Kristine B.;Dale, Anders M.
通讯作者：
Dale, Anders M.
影响因子：
8.3
作者：
DeCarli, C;Fletcher, E;Jagust, WJ
通讯作者：
Jagust, WJ
影响因子：
19.7
作者：
Courchesne, E;Chisum, HJ;Press, GA
通讯作者：
Press, GA