Hippocampus-dependent learning influences hippocampal neurogenesis.
Hippocampus-dependent learning influences hippocampal neurogenesis.
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DOI：
10.3389/fnins.2013.00057
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发表时间：
2013
影响因子：
4.3
通讯作者：
Galea LA
中科院分区：
文献类型：
--
作者：
Epp JR;Chow C;Galea LA
哺乳动物海马体的结构在整个生命过程中通过在齿状回中不断添加神经元而不断修改。虽然成体神经发生的存在现在被广泛接受，但成体产生的颗粒细胞所发挥的功能是一个激烈争论的话题。许多研究认为，成人产生的神经元，由于其独特的生理特性，在海马依赖的学习和记忆中发挥着独特的作用。然而，目前尚不清楚是否是这种情况，或者成年产生的神经元可能赋予发育产生的神经元没有的特定能力。这些问题已经以多种方式解决，从检查增加或减少神经发生的影响到计算建模。一个特定的研究领域已经研究了海马依赖性学习对未成熟神经元响应记忆提取的增殖、存活、整合和激活的影响。在这一领域内，仍然有一系列的数据表明，海马依赖性学习可能会增加，减少或替代地可能不会改变海马中神经发生的这些组成部分。确定依赖于海马的学习如何以及何时改变成人神经发生将有助于进一步阐明成人生成神经元的作用。有许多变量（如未成熟神经元的年龄，物种，应变，性别，压力，任务难度和学习类型）以及许多方法学差异（如标记类型，量化技术，设备大小等）。这些都可能是理解学习和神经发生之间相互作用的关键。在这里，我们回顾这些发现，并讨论了不同的条件下，依赖于海马的学习影响成年人的齿状回神经发生。
The structure of the mammalian hippocampus continues to be modified throughout life by continuous addition of neurons in the dentate gyrus. Although the existence of adult neurogenesis is now widely accepted the function that adult generated granule cells play is a topic of intense debate. Many studies have argued that adult generated neurons, due to unique physiological characteristics, play a unique role in hippocampus-dependent learning and memory. However, it is not currently clear whether this is the case or what specific capability adult generated neurons may confer that developmentally generated neurons do not. These questions have been addressed in numerous ways, from examining the effects of increasing or decreasing neurogenesis to computational modeling. One particular area of research has examined the effects of hippocampus dependent learning on proliferation, survival, integration and activation of immature neurons in response to memory retrieval. Within this subfield there remains a range of data showing that hippocampus dependent learning may increase, decrease or alternatively may not alter these components of neurogenesis in the hippocampus. Determining how and when hippocampus-dependent learning alters adult neurogenesis will help to further clarify the role of adult generated neurons. There are many variables (such as age of immature neurons, species, strain, sex, stress, task difficulty, and type of learning) as well as numerous methodological differences (such as marker type, quantification techniques, apparatus size etc.) that could all be crucial for a clear understanding of the interaction between learning and neurogenesis. Here, we review these findings and discuss the different conditions under which hippocampus-dependent learning impacts adult neurogenesis in the dentate gyrus.
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影响因子：
9.8
作者：
Dupret D;Fabre A;Döbrössy MD;Panatier A;Rodríguez JJ;Lamarque S;Lemaire V;Oliet SH;Piazza PV;Abrous DN
通讯作者：
Abrous DN
影响因子：
2.5
作者：
Ehninger, D;Kempermann, G
通讯作者：
Kempermann, G
影响因子：
2.5
作者：
Brown, JP;Couillard-Després, S;Kuhn, HG
通讯作者：
Kuhn, HG
DOI：
10.1073/pnas.0809650106
发表时间：
2009-02-24
影响因子：
11.1
作者：
Dalla, Christina;Papachristos, Efstathios B.;Shors, Tracey J.
通讯作者：
Shors, Tracey J.
影响因子：
3.4
作者：
Couillard-Despres, S;Winner, B;Aigner, L
通讯作者：
Aigner, L