Bone marrow-derived stromal cell therapy in cirrhosis: clinical evidence, cellular mechanisms, and implications for the treatment of hepatocellular carcinoma.

Bone marrow-derived stromal cell therapy in cirrhosis: clinical evidence, cellular mechanisms, and implications for the treatment of hepatocellular carcinoma.
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DOI:
10.1016/j.ijrobp.2014.02.017
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发表时间:
2014-07-15
影响因子:
7
通讯作者:
Guha, Chandan
Guha, Chandan
中科院分区:
医学1区
文献类型:
--
作者:
Vainshtein, Jeffrey M.;Kabarriti, Rafi;Mehta, Keyur J.;Roy-Chowdhury, Jayanta;Guha, Chandan

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肝细胞癌(HCC)是全球第五大常见恶性肿瘤,每年占癌症死亡人数的近10%。对于肝功能保存良好且病变范围有限的患者,手术切除提供了最好的治愈机会。然而,对于80%的肝细胞癌患者,肝移植仍然是唯一可用的治愈性治疗,并且仅适用于Child-Pugh(C-P)A级或B级患者。即使在符合移植条件的患者中,可用供体肝脏的短缺也严重限制了最终接受移植的HCC患者的数量。因此,对于大多数肝癌患者,其中存在于晚期或具有显著的肝功能障碍,非手术干预仍然是唯一的治疗选择。
Hepatocellular carcinoma (HCC) is the 5th most common malignancy worldwide and accounts for nearly 10% of cancer deaths annually. In patients with well-preserved liver function and limited disease, surgical resection offers the best chance of cure. For the 80% of HCC patients with underlying cirrhosis, however, liver transplantation remains the only available curative treatment, and then only in Child-Pugh (C-P) class A or B patients. Even in transplant-eligible patients, the shortage of available donor livers severely limits the number of HCC patients that ultimately undergo transplantation. Thus, for the majority of HCC patients, which present at advanced stage or with significant liver dysfunction, non-surgical interventions remain the only treatment option.
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