Bone marrow-derived stromal cell therapy in cirrhosis: clinical evidence, cellular mechanisms, and implications for the treatment of hepatocellular carcinoma.
Bone marrow-derived stromal cell therapy in cirrhosis: clinical evidence, cellular mechanisms, and implications for the treatment of hepatocellular carcinoma.
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DOI:
10.1016/j.ijrobp.2014.02.017
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发表时间:
2014-07-15
影响因子:
7
通讯作者:
Guha, Chandan
中科院分区:
文献类型:
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作者:
Vainshtein, Jeffrey M.;Kabarriti, Rafi;Mehta, Keyur J.;Roy-Chowdhury, Jayanta;Guha, Chandan
Hepatocellular carcinoma (HCC) is the 5th most common malignancy worldwide and accounts for nearly 10% of cancer deaths annually. In patients with well-preserved liver function and limited disease, surgical resection offers the best chance of cure. For the 80% of HCC patients with underlying cirrhosis, however, liver transplantation remains the only available curative treatment, and then only in Child-Pugh (C-P) class A or B patients. Even in transplant-eligible patients, the shortage of available donor livers severely limits the number of HCC patients that ultimately undergo transplantation. Thus, for the majority of HCC patients, which present at advanced stage or with significant liver dysfunction, non-surgical interventions remain the only treatment option.
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