Murine Axial Compression Tibial Loading Model to Study Bone Mechanobiology: Implementing the Model and Reporting Results.
Murine Axial Compression Tibial Loading Model to Study Bone Mechanobiology: Implementing the Model and Reporting Results.
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DOI：
10.1002/jor.24466
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发表时间：
2020-02
影响因子：
2.8
通讯作者：
Willie, Bettina M.
中科院分区：
文献类型：
--
作者：
Main, Russell P.;Shefelbine, Sandra J.;Meakin, Lee B.;Silva, Matthew J.;van der Meulen, Marjolein C. H.;Willie, Bettina M.
小鼠体内胫骨载荷越来越多地用于研究骨适应和机械传导。为了实现标准化和定义的实验条件，在进行体内负载研究时必须考虑负载参数和动物相关因素。在这篇综述中，我们讨论了这些负载和动物相关的实验条件，目前的方法来评估骨适应，并建议报告准则。本综述源于每位作者在2017年3月在加利福尼亚州圣地亚哥举行的骨科研究学会年会的临床前模型部分期间举办的研讨会“开发体内加载小鼠模型的最佳实践”上的演讲。会后，作者们进行了详细讨论，并考虑了相关文献。在这篇评论中的指导方针和建议，以帮助研究人员在小鼠体内进行负载实验，从而进一步了解骨适应和机械转导的机制。
In vivo tibial loading in mice is increasingly used to study bone adaptation and mechanotransduction. To achieve standardized and defined experimental conditions, loading parameters and animal-related factors must be considered when performing in vivo loading studies. In this review we discuss these loading and animal-related experimental conditions, present methods to assess bone adaptation, and suggest reporting guidelines. This review originated from presentations by each of the authors at the workshop “Developing Best Practices for Mouse Models of In Vivo Loading” during the Preclinical Models Section at the Orthopaedic Research Society Annual Meeting, San Diego, CA, March 2017. Following the meeting, the authors engaged in detailed discussions with consideration of relevant literature. The guidelines and recommendations in this review are provided to help researchers perform in vivo loading experiments in mice, and thus further our knowledge of bone adaptation and the mechanisms involved in mechanotransduction.
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DOI：
10.1007/s00198-016-3846-6
发表时间：
2017-03
期刊：
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
影响因子：
--
作者：
Bergström I;Kerns JG;Törnqvist AE;Perdikouri C;Mathavan N;Koskela A;Henriksson HB;Tuukkanen J;Andersson G;Isaksson H;Goodship AE;Windahl SH
通讯作者：
Windahl SH
影响因子：
2.5
作者：
Carrieroa A;Pereirab AF;Wilson AJ;Castagno S;Javaheri B;Pitsillides AA;Marenzana M;Shefelbine SJ
通讯作者：
Shefelbine SJ
影响因子：
3.7
作者：
Berman AG;Clauser CA;Wunderlin C;Hammond MA;Wallace JM
通讯作者：
Wallace JM
影响因子：
4.1
作者：
Altman AR;Tseng WJ;de Bakker CMJ;Chandra A;Lan S;Huh BK;Luo S;Leonard MB;Qin L;Liu XS
通讯作者：
Liu XS
影响因子：
4.1
作者：
Birkhold, Annette I.;Razi, Hajar;Willie, Bettina M.
通讯作者：
Willie, Bettina M.