Current status and future directions of invasive pneumococcal diseases and prophylactic approaches to control them.
Current status and future directions of invasive pneumococcal diseases and prophylactic approaches to control them.
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DOI：
10.1080/21645515.2018.1470726
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发表时间：
2018
影响因子：
4.8
通讯作者：
Avci FY
中科院分区：
文献类型：
--
作者：
Wantuch PL;Avci FY
肺炎链球菌是一种主要的人类细菌病原体，每年造成数百万人死亡，并在世界范围内引起更多的疾病。有超过90种不同的血清型，提供有效的疫苗计划一直是一个持续的挑战。自1983年以来，世界上已经引入了四种不同的肺炎球菌疫苗（PPSV23，PCV 7，PCV 10和PCV 13），每种疫苗都有自己的并发症和成功。自疫苗接种计划开始以来，肺炎球菌肺炎和相关疾病的总体发病率有所下降，特别是在高危人群中。然而，随着疫苗型肺炎球菌血清型发生率的降低，随着血清型转换，沿着观察到细菌的非疫苗血清型增加。此外，S.注意到肺炎。在这里，我们讨论了肺炎疫苗项目的阳性和阴性临床表现，并讨论了肺炎球菌疫苗设计的挑战。
Streptococcus pneumoniae is a major human bacterial pathogen responsible for millions of deaths each year and significantly more illnesses worldwide. With over 90 different serotypes, providing effective vaccine programs has been a continuing challenge. Since 1983, the world has been introduced to four different pneumococcal vaccines (PPSV23, PCV7, PCV10, and PCV13) each with their own complications and successes. Since vaccination programs began, a decrease in the overall rate of pneumococcal pneumonia and associated diseases has been observed, notably in higher risk populations. However, with a decrease in incidence of vaccine type pneumococcal serotypes, increases in non-vaccine serotypes of the bacteria have been observed along with serotype switching. Additionally, a rise in antibiotic resistant strains of S. pneumoniae is noted. Here we discuss both the positive and negative clinical manifestations of pneumonia vaccine programs and discuss the challenges in pneumococcal vaccine design.
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