Draft genome of Ochrobactrum intermedium strain M86 isolated from non-ulcer dyspeptic individual from India.
Draft genome of Ochrobactrum intermedium strain M86 isolated from non-ulcer dyspeptic individual from India.
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DOI：
10.1186/1757-4749-5-7
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发表时间：
2013-04-04
期刊：
影响因子：
4.2
通讯作者：
Shouche Y
中科院分区：
文献类型：
--
作者：
Kulkarni G;Dhotre D;Dharne M;Shetty S;Chowdhury S;Misra V;Misra S;Patole M;Shouche Y
中间苍白杆菌是一种新出现的人类机会致病菌，与布鲁氏菌属成员密切相关。早些时候，我们报道了一名患有非溃疡性消化不良症状的印度受试者的病例，其尿素酶阳性胃活检显示存在幽门螺杆菌以及非螺杆菌样细菌，最终培养并鉴定为中间型 O. 菌株 M86。在这里，我们描述了菌株 M86 的未封闭基因组草图，长度为 5,188,688 bp，平均 G+C 含量为 57.9%。我们还鉴定了许多可能导致其在胃粘膜中持久存在的推定基因簇。还对中间苍白杆菌菌株 M86 和中间苍白杆菌 LMG 3301T 的基因组特征进行了比较分析。本文试图从全基因组的基础上深入了解 O. intermedium 在高酸性胃腔环境中生存的假定基因决定因素。鉴定出假定参与各种代谢途径的基因可能有助于更好地了解 O. intermedium 在酸性条件下的生存。
Ochrobactrum intermedium is an emerging opportunistic pathogen of humans that is closely related to members of the genus Brucella. Earlier, we reported the case of an Indian subject with non-ulcer dyspeptic symptoms whose urease positive gastric biopsy revealed the presence of Helicobacter pylori along with non-Helicobacter like bacteria, eventually cultured and identified as O. intermedium strain M86. Here, we describe the unclosed draft genome of the strain M86 with a length of 5,188,688 bp and mean G+C content of 57.9%. We have also identified many putative gene clusters that might be responsible for its persistence in the gastric mucosa.Comparative analysis of genomic features of Ochrobactrum intermedium strain M86 and Ochrobactrum intermedium LMG 3301T was also done. This paper attempts to gain whole-genome based insights into the putative gene determinants of O. intermedium for survival in the highly acidic stomach lumen environment .Identification of genes putatively involved in the various metabolic pathways may lead to a better understanding of the survival of O. intermdedium in acidic condition.
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