A novel porous mechanical framework for modelling the interaction between coronary perfusion and myocardial mechanics.
A novel porous mechanical framework for modelling the interaction between coronary perfusion and myocardial mechanics.
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DOI：
10.1016/j.jbiomech.2011.11.026
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发表时间：
2012-03-15
影响因子：
2.4
通讯作者：
Smith NP
中科院分区：
文献类型：
--
作者：
Cookson AN;Lee J;Michler C;Chabiniok R;Hyde E;Nordsletten DA;Sinclair M;Siebes M;Smith NP
冠状动脉内的血流和心肌组织的机械变形之间的强耦合是心脏生理学的一个中心特征，因此必须用冠脉血流灌注模型来解释。目前已有的几何显式血管模型不能令人满意地捕捉到这种相互作用，对于整个器官的模拟在数值上是困难的，并且很难在人类环境中进行参数化。为了解决这些问题，在这项研究中，提出了一个不可压缩的，多孔弹性的心肌灌注模型的有限元公式。利用冠状动脉树的高分辨率体外成像数据，将多孔介质的渗透性张量映射到相应的左心室几何网格上。合成的张量场不仅表征了实验数据中观察到的不同的灌注区，而且通过多室多孔模型表征了冠状动脉树中存在的广泛的血管长度尺度。有限变形力学是使用宏观本构定律求解的，该定律定义了多孔介质的流固相之间的耦合。结果显示了在被动充气状态下左心室的灌注，显示了与灌注相关的室壁硬化，并表明了在特定的灌注区内非分级多间隔模型的意义。
The strong coupling between the flow in coronary vessels and the mechanical deformation of the myocardial tissue is a central feature of cardiac physiology and must therefore be accounted for by models of coronary perfusion. Currently available geometrically explicit vascular models fail to capture this interaction satisfactorily, are numerically intractable for whole organ simulations, and are difficult to parameterise in human contexts. To address these issues, in this study, a finite element formulation of an incompressible, poroelastic model of myocardial perfusion is presented. Using high-resolution ex vivo imaging data of the coronary tree, the permeability tensors of the porous medium were mapped onto a mesh of the corresponding left ventricular geometry. The resultant tensor field characterises not only the distinct perfusion regions that are observed in experimental data, but also the wide range of vascular length scales present in the coronary tree, through a multi-compartment porous model. Finite deformation mechanics are solved using a macroscopic constitutive law that defines the coupling between the fluid and solid phases of the porous medium. Results are presented for the perfusion of the left ventricle under passive inflation that show wall-stiffening associated with perfusion, and that show the significance of a non-hierarchical multi-compartment model within a particular perfusion territory.
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DOI：
10.1152/ajpheart.00486.2010
发表时间：
2011-03-01
影响因子：
4.8
作者：
Kaneko, Noboru;Matsuda, Ryuko;Shimamoto, Ken
通讯作者：
Shimamoto, Ken
影响因子：
--
作者：
HUYGHE, JM;ARTS, T;RENEMAN, RS
通讯作者：
RENEMAN, RS
DOI：
10.1098/rsta.2001.0829
发表时间：
2001-06-15
影响因子：
5
作者：
Smith, NP;Kassab, GS
通讯作者：
Kassab, GS
影响因子：
--
作者：
KRAMS, R;SIPKEMA, P;WESTERHOF, N
通讯作者：
WESTERHOF, N
DOI：
10.1152/ajpheart.1998.274.2.h405
发表时间：
1998-02-01
影响因子：
4.8
作者：
Dijkman, MA;Heslinga, JW;Westerhof, N
通讯作者：
Westerhof, N