Phase and Frequency-Dependent Effects of Transcranial Alternating Current Stimulation on Motor Cortical Excitability.
Phase and Frequency-Dependent Effects of Transcranial Alternating Current Stimulation on Motor Cortical Excitability.
复制标题
经颅交流刺激对运动皮质兴奋性的相位和频率依赖性影响。
DOI：
10.1371/journal.pone.0162521
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Tobimatsu S
中科院分区：
文献类型：
--
作者：
Nakazono H;Ogata K;Kuroda T;Tobimatsu S
经颅交流电刺激（tACS）可以携带正在进行的大脑振荡，并以频率依赖的方式调节运动系统。最近的动物研究表明，正弦电流的相位在神经元活动的调节中也起着重要作用。然而，tACS对人体运动系统的相位效应在很大程度上是未知的。本研究采用经颅磁刺激（TMS）的运动诱发电位（MEPs）系统地研究了tACS相位和频率对初级运动皮层（M1）的影响。首先，我们比较了10和20 Hz tACS在mep上的相位效应（90°，180°，270°或360°）。与仅90°相的10 Hz相比，20 Hz tACS显著增加了M1的兴奋性。其次，我们研究了不同tACS频率（5、10、20或40 Hz）下90°相位对mep的影响。再次观察到20和10 Hz的差异，但在5和40 Hz的tACS中90°相位不影响M1兴奋性。第三，将10 Hz和20 Hz的tACS的90°相位效应与假刺激进行比较。与假刺激相比，90°相位的20 Hz tACS增强了MEP振幅，但10 Hz tACS无显著影响。综上所述，我们认为在20 Hz和10 Hz tACS上的90°相位差效应可归因于tACS调制的神经同步。我们的研究结果进一步强调了相位和频率是tACS对M1兴奋性影响的重要因素。
Transcranial alternating current stimulation (tACS) can entrain ongoing brain oscillations and modulate the motor system in a frequency-dependent manner. Recent animal studies have demonstrated that the phase of a sinusoidal current also has an important role in modulation of neuronal activity. However, the phase effects of tACS on the human motor system are largely unknown. Here, we systematically investigated the effects of tACS phase and frequency on the primary motor cortex (M1) by using motor evoked potentials (MEPs) with transcranial magnetic stimulation (TMS). First, we compared the phase effects (90°, 180°, 270° or 360°) of 10 and 20 Hz tACS on MEPs. The 20 Hz tACS significantly increased M1 excitability compared with the 10 Hz tACS at 90° phase only. Second, we studied the 90° phase effect on MEPs at different tACS frequencies (5, 10, 20 or 40 Hz). The 20 vs. 10 Hz difference was again observed, but the 90° phase in 5 and 40 Hz tACS did not influence M1 excitability. Third, the 90° phase effects of 10 and 20 Hz tACS were compared with sham stimulation. The 90° phase of 20 Hz tACS enhanced MEP amplitudes compared with sham stimulation, but there was no significant effect of 10 Hz tACS. Taken together, we assume that the differential 90° phase effects on 20 Hz and 10 Hz tACS can be attributed to the neural synchronization modulated by tACS. Our results further underline that phase and frequency are the important factors in the effects of tACS on M1 excitability.
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影响因子：
9.2
作者：
Joundi, Raed A.;Jenkinson, Ned;Brittain, John-Stuart;Aziz, Tipu Z.;Brown, Peter
通讯作者：
Brown, Peter
影响因子：
2.5
作者：
Keil, Julian;Timm, Jana;Schoenwiesner, Marc
通讯作者：
Schoenwiesner, Marc
影响因子：
5.3
作者：
Feurra, Matteo;Pasqualetti, Patrizio;Rossi, Simone
通讯作者：
Rossi, Simone
影响因子：
2.9
作者：
Herrmann CS;Rach S;Neuling T;Strüber D
通讯作者：
Strüber D
DOI：
10.1016/j.cub.2014.11.034
发表时间：
2015-01-19
期刊：
Current biology : CB
影响因子：
--
作者：
Cecere R;Rees G;Romei V
通讯作者：
Romei V