Transcranial alternating current stimulation: a review of the underlying mechanisms and modulation of cognitive processes.

Transcranial alternating current stimulation: a review of the underlying mechanisms and modulation of cognitive processes.
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DOI:
10.3389/fnhum.2013.00279
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发表时间:
2013
影响因子:
2.9
通讯作者:
Strüber D
Strüber D
中科院分区:
医学3区
文献类型:
--
作者:
Herrmann CS;Rach S;Neuling T;Strüber D

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不同频率的大脑振荡与多种认知功能有关。颅内刺激、药理学干预和病变研究提供了支持这些关联的令人信服的证据。新的非侵入性脑刺激技术的出现,如重复经颅磁刺激(rTMS)和经颅交流电刺激(tACS),现在可以直接调节大脑振荡。特别是,tACS提供了一个独特的机会,将特定频率范围内的大脑振荡与认知过程因果联系起来,因为它使用的是只绑定在一个频率上的正弦电流。使用tACS可以调节大脑振荡,进而影响认知过程,从而证明两者之间的因果关系。在此,我们综述了tACS的生理机制,以及利用tACS调节基本运动和感觉过程以及记忆、模糊感知和决策等高级认知过程的研究结果。
Brain oscillations of different frequencies have been associated with a variety of cognitive functions. Convincing evidence supporting those associations has been provided by studies using intracranial stimulation, pharmacological interventions and lesion studies. The emergence of novel non-invasive brain stimulation techniques like repetitive transcranial magnetic stimulation (rTMS) and transcranial alternating current stimulation (tACS) now allows to modulate brain oscillations directly. Particularly, tACS offers the unique opportunity to causally link brain oscillations of a specific frequency range to cognitive processes, because it uses sinusoidal currents that are bound to one frequency only. Using tACS allows to modulate brain oscillations and in turn to influence cognitive processes, thereby demonstrating the causal link between the two. Here, we review findings about the physiological mechanism of tACS and studies that have used tACS to modulate basic motor and sensory processes as well as higher cognitive processes like memory, ambiguous perception, and decision making.
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