Novel Composite Microparticles of Alginate Coated with Chitosan for Controlled Release and Protection of Ascorbic Acid
Novel Composite Microparticles of Alginate Coated with Chitosan for Controlled Release and Protection of Ascorbic Acid
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壳聚糖包覆的新型海藻酸盐复合微粒用于抗坏血酸的控释和保护
DOI：
10.1002/adv.21574
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发表时间：
2017-03
影响因子：
3.1
通讯作者：
林宝凤
中科院分区：
文献类型：
--
作者：
赖凤娇;林宝凤
采用离子型/外部凝胶化技术制备了壳聚糖（CS）包覆海藻酸钠（ALG）的新型复合微球，用于抗氧化剂抗坏血酸（AA）的控释和保护。采用傅里叶变换红外光谱、X射线衍射和扫描电子显微镜对微粒进行了表征。包封率为89.94 ± 5.62%，载药量为37.01 ± 1.83%。在pH 7下的微粒的溶胀度远高于在pH 2.0下的溶胀度。释放曲线表明，AA可以从微粒中缓慢释放，聚合物松弛是主要的释放机制。ALG/CS微粒对AA的光和热暴露降解具有保护作用。紫外线照射7 d后，80°C加热，AA微粒中AA的残留率分别为90.31%和83.32%，远高于游离AA的15.72%和19.95%。结果表明，ALG/CS微粒可作为AA的可靠给药系统。
Novel composite microparticles of alginate (ALG) coated with chitosan (CS) were prepared via ionotropic/external gelation technique for controlled release and protection of ascorbic acid (AA), a strong antioxidant. The microparticles were characterized by Fourier transform infrared, X-ray diffraction, and scanning electron microscopy. The encapsulation efficiency and loading capacity were 89.94 ± 5.62% and 37.01 ± 1.83%, respectively. The degree of swelling of the microparticles at pH 7 was much higher than that at pH 2.0. The release profiles showed that AA could be slowly released from microparticles and polymeric relaxation was the prevailing release mechanism. The ALG/CS microparticles exhibited protective effect on AA against light and heat exposure degradation. After 7 days of ultraviolet exposure and 80°C heating, the residual rates of AA in AA-loaded microparticles were 90.31% and 83.32%, which were much higher than 15.72% and 19.95% for free AA. The results suggested that the ALG/CS microparticles can be used as a reliable delivery system for AA.
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DOI：
10.1016/j.ifset.2012.06.004
发表时间：
2012-10-01
影响因子：
6.6
作者：
Pinheiro, Ana C.;Bourbon, Ana I.;Vicente, Antonio A.
通讯作者：
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DOI：
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发表时间：
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期刊：
Journal of Macromolecular Science, Part A
影响因子：
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影响因子：
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影响因子：
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