Community member perspectives from transgender women and men who have sex with men on pre-exposure prophylaxis as an HIV prevention strategy: implications for implementation.
Community member perspectives from transgender women and men who have sex with men on pre-exposure prophylaxis as an HIV prevention strategy: implications for implementation.
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DOI：
10.1186/1748-5908-7-116
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发表时间：
2012-11-26
期刊：
影响因子：
--
通讯作者：
Arnold EA
中科院分区：
文献类型：
--
作者：
Galindo GR;Garrett-Walker JJ;Hazelton P;Lane T;Steward WT;Morin SF;Arnold EA
一项关于暴露前预防（PrEP）作为人类免疫缺陷病毒（HIV）预防干预措施的国际随机临床试验（RCT）发现，每天服用PrEP对男性同性恋者（MSM）和男性对女性变性女性安全有效。在美国艾滋病毒流行的背景下，男男性行为者和变性妇女是在人口水平上实施PrEP的最合适群体;然而，他们对循证生物医学研究的观点和这项大型试验的结果仍然几乎未知。在这项研究中，我们检查了个人日常使用PrEP的可接受性，并评估了社区吸收的潜在障碍。我们在加州的三个大都市区对30名HIV阴性和身份不明的MSM（n = 24）和变性妇女（n = 6）进行了半结构化访谈。考虑到美国少数民族的疾病负担，我们有目的地对这些群体进行了过度采样。专题编码和数据分析进行了利用扎根于扎根理论的方法。虽然参与者对PrEP的可用性表示了普遍的兴趣，但结果表明：缺乏社区意识和对PrEP的困惑;对PrEP使用的保留意见，即使被告知有效的RCT结果;以及对PrEP干预措施在社区包装和营销的公平性和方式的担忧。为了有效地减少人口一级的艾滋病毒健康差异，PrEP的实施必须考虑到那些实际获得和使用这种生物医学干预作为预防战略的群体的关注。针对这些问题提出了建议。本文的在线版本（doi：10.1186/1748-5908-7-116）包含补充材料，可供授权用户使用。
An international randomized clinical trial (RCT) on pre-exposure prophylaxis (PrEP) as an human immunodeficiency virus (HIV)-prevention intervention found that taken on a daily basis, PrEP was safe and effective among men who have sex with men (MSM) and male-to-female transgender women. Within the context of the HIV epidemic in the United States (US), MSM and transgender women are the most appropriate groups to target for PrEP implementation at the population level; however, their perspectives on evidenced-based biomedical research and the results of this large trial remain virtually unknown. In this study, we examined the acceptability of individual daily use of PrEP and assessed potential barriers to community uptake. We conducted semi-structured interviews with an ethnoracially diverse sample of thirty HIV-negative and unknown status MSM (n = 24) and transgender women (n = 6) in three California metropolitan areas. Given the burden of disease among ethnoracial minorities in the US, we purposefully oversampled for these groups. Thematic coding and analysis of data was conducted utilizing an approach rooted in grounded theory. While participants expressed general interest in PrEP availability, results demonstrate: a lack of community awareness and confusion about PrEP; reservations about PrEP utilization, even when informed of efficacious RCT results; and concerns regarding equity and the manner in which a PrEP intervention could be packaged and marketed in their communities. In order to effectively reduce HIV health disparities at the population level, PrEP implementation must take into account the uptake concerns of those groups who would actually access and use this biomedical intervention as a prevention strategy. Recommendations addressing these concerns are provided. The online version of this article (doi:10.1186/1748-5908-7-116) contains supplementary material, which is available to authorized users.
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影响因子：
168.9
作者：
Beyrer, Chris;Sullivan, Patrick S.;Sanchez, Jorge;Dowdy, David;Altman, Dennis;Trapence, Gift;Collins, Chris;Katabira, Elly;Kazatchkine, Michel;Sidibe, Michel;Mayer, Kenneth H.
通讯作者：
Mayer, Kenneth H.
DOI：
10.1097/qai.0b013e3181e19a54
发表时间：
2010-08
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Golub SA;Kowalczyk W;Weinberger CL;Parsons JT
通讯作者：
Parsons JT
影响因子：
1.7
作者：
Brooks RA;Kaplan RL;Lieber E;Landovitz RJ;Lee SJ;Leibowitz AA
通讯作者：
Leibowitz AA
影响因子：
2.7
作者：
Godin, G;Kok, G
通讯作者：
Kok, G
影响因子：
2.9
作者：
Davis, M;Hart, G;Elford, J
通讯作者：
Elford, J