Motor cortical activity changes during neuroprosthetic-controlled object interaction.
Motor cortical activity changes during neuroprosthetic-controlled object interaction.
复制标题
DOI：
10.1038/s41598-017-17222-3
复制
发表时间：
2017-12-05
影响因子：
4.6
通讯作者：
Collinger JL
中科院分区：
文献类型：
--
作者：
Downey JE;Brane L;Gaunt RA;Tyler-Kabara EC;Boninger ML;Collinger JL
脑机接口(BCI)控制的假肢正在开发中，以恢复上肢瘫痪患者的功能。这项工作为分析复杂任务中的人类大脑皮层活动提供了机会。在此之前，我们观察到脑机接口控制在与物体的交互过程中变得更加困难，尽管我们没有量化这一现象的神经起源。在这里，我们研究了在物体存在的情况下，运动皮质活动是如何改变的，而不是使用两个四肢瘫痪患者的皮质内记录产生的运动学。在确定了与手靠近物体相对应的整个人群的神经放电率的增加后，我们在BCI系统中开发了一个在线缩放功能，该功能在不知道任务的情况下进行操作。在线伸缩增加了两个受试者在伸手抓取和运输物体时控制机械臂的能力。这项工作表明，环境的神经表征，在这种情况下，物体的存在，在运动皮质中得到强烈和一致的表征，但可以解释为改善脑机接口的性能。
Brain-computer interface (BCI) controlled prosthetic arms are being developed to restore function to people with upper-limb paralysis. This work provides an opportunity to analyze human cortical activity during complex tasks. Previously we observed that BCI control became more difficult during interactions with objects, although we did not quantify the neural origins of this phenomena. Here, we investigated how motor cortical activity changed in the presence of an object independently of the kinematics that were being generated using intracortical recordings from two people with tetraplegia. After identifying a population-wide increase in neural firing rates that corresponded with the hand being near an object, we developed an online scaling feature in the BCI system that operated without knowledge of the task. Online scaling increased the ability of two subjects to control the robotic arm when reaching to grasp and transport objects. This work suggests that neural representations of the environment, in this case the presence of an object, are strongly and consistently represented in motor cortex but can be accounted for to improve BCI performance.
登录
查看更多内容
影响因子：
64.8
作者：
Ethier, C.;Oby, E. R.;Bauman, M. J.;Miller, L. E.
通讯作者：
Miller, L. E.
影响因子：
17.1
作者：
Jarosiewicz B;Sarma AA;Bacher D;Masse NY;Simeral JD;Sorice B;Oakley EM;Blabe C;Pandarinath C;Gilja V;Cash SS;Eskandar EN;Friehs G;Henderson JM;Shenoy KV;Donoghue JP;Hochberg LR
通讯作者：
Hochberg LR
影响因子：
2.9
作者：
MATHIOWETZ, V;VOLLAND, G;WEBER, K
通讯作者：
WEBER, K
影响因子：
1.7
作者：
Kirshblum, Steven C.;Waring, William;Krassioukov, Andrei
通讯作者：
Krassioukov, Andrei
影响因子：
4
作者：
Menz, Veera Katharina;Schaffelhofer, Stefan;Scherberger, Hansjoerg
通讯作者：
Scherberger, Hansjoerg