Accelerated DNA methylation changes in middle-aged men define sexual dimorphism in human lifespans.
Accelerated DNA methylation changes in middle-aged men define sexual dimorphism in human lifespans.
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中年男性 DNA 甲基化的加速变化定义了人类寿命中的性别二态性
DOI：
10.1186/s13148-018-0573-1
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发表时间：
2018-10-29
影响因子：
5.7
通讯作者：
Kong QP
中科院分区：
文献类型：
--
作者：
Xiao FH;Chen XQ;He YH;Kong QP
背景男性中加速的年龄相关DNA甲基化变化可以解释年龄相关疾病的早期发病（例如，心血管疾病（CVD）），因此有助于两性异形的发病率和寿命。然而，关于出现这种性别偏见的甲基化模式的细节仍然不清楚。ResultsTo解决这些问题，我们收集了公开可用的外周血甲基化数据集检测Illumina HumanMethylation 450 BeadChip平台从四个研究，包含年龄和性别信息的样本。我们分析了从708名欧洲血统受试者中筛选的外周血甲基化数据。结果显示，中年男性（40-50岁）的甲基化变化显著加速，这得到了另一个包含2711名印度血统受试者的队列的进一步支持。额外的分析表明，这些性二态甲基化变化在与CVD相关的基因中显著过度表达，这可能影响疾病表达的潜在激活。此外，我们发现，较高的患病率的饮酒和吸烟的男性有一定的贡献，以性别为基础的甲基化模式在aging.ConclusionOur结果表明，性别偏见的甲基化变化发生在中年男性的加速方式，并可能有助于性二态性观察在人类寿命促进CVD的发生。由于饮酒和吸烟也被发现与男性的这种加速甲基化变化有关，因此在中年或中年之前改善不健康的生活方式可能会延长男性寿命。
BackgroundAccelerated age-associated DNA methylation changes in males may explain the earlier onset of age-related diseases (e.g., cardiovascular disease (CVD)) and thus contribute to sexually dimorphic morbidity and lifespan. However, the details regarding the emergence of this sex-biased methylation pattern remain unclear.ResultsTo address these issues, we collected publicly available peripheral blood methylation datasets detected by Illumina HumanMethylation450 BeadChip platform from four studies that contain age and gender information of samples. We analyzed peripheral blood methylation data screened from 708 subjects of European ancestry. Results revealed a significant methylation change acceleration in middle-aged males (40–50 years old), which was further supported by another cohort containing 2711 subjects with Indian ancestry. Additional analyses suggested that these sexually dimorphic methylation changes were significantly overrepresented in genes associated with CVD, which may impact the potential activation of disease expression. Furthermore, we showed that higher prevalence of drinking and smoking in the males has some contribution to the sex-based methylation patterns during aging.ConclusionOur results indicated that the sex-biased methylation changes occurred in middle-aged men in an acceleration manner and likely contribute to the sexual dimorphism observed in human lifespan by promoting the occurrence of CVD. As drinking and smoking were also found to be associated with this accelerated methylation change in men, it is possible that male lifespan may be prolonged by improving unhealthy lifestyles at or before middle age.
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影响因子：
7.8
作者：
Masser DR;Hadad N;Porter HL;Mangold CA;Unnikrishnan A;Ford MM;Giles CB;Georgescu C;Dozmorov MG;Wren JD;Richardson A;Stanford DR;Freeman WM
通讯作者：
Freeman WM
全基因组甲基化谱揭示了人类衰老速度的定量观点。
影响因子：
16
作者：
Hannum, Gregory;Guinney, Justin;Zhao, Ling;Zhang, Li;Hughes, Guy;Sadda, SriniVas;Klotzle, Brandy;Bibikova, Marina;Fan, Jian-Bing;Gao, Yuan;Deconde, Rob;Chen, Menzies;Rajapakse, Indika;Friend, Stephen;Ideker, Trey;Zhang, Kang
通讯作者：
Zhang, Kang
影响因子：
3.7
作者：
Philibert RA;Penaluna B;White T;Shires S;Gunter T;Liesveld J;Erwin C;Hollenbeck N;Osborn T
通讯作者：
Osborn T
DOI：
10.1152/physiol.00041.2008
发表时间：
2009-04
期刊：
Physiology (Bethesda, Md.)
影响因子：
--
作者：
Mauban JR;O'Donnell M;Warrier S;Manni S;Bond M
通讯作者：
Bond M
DOI：
10.1093/database/baq020
发表时间：
2010-08-05
期刊：
Database : the journal of biological databases and curation
影响因子：
--
作者：
Safran M;Dalah I;Alexander J;Rosen N;Iny Stein T;Shmoish M;Nativ N;Bahir I;Doniger T;Krug H;Sirota-Madi A;Olender T;Golan Y;Stelzer G;Harel A;Lancet D
通讯作者：
Lancet D