Urinary phytoestrogens and depression in perimenopausal US women: NHANES 2005-2008.
Urinary phytoestrogens and depression in perimenopausal US women: NHANES 2005-2008.
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美国围绝经期女性的尿液植物雌激素与抑郁症：NHANES 2005-2008。
DOI：
10.1016/j.jad.2013.12.029
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发表时间：
2014
影响因子：
6.6
通讯作者：
M. Eichholzer
中科院分区：
文献类型：
--
作者：
A. Richard;S. Rohrmann;M. Mohler;S. Rodgers;R. Moffat;U. Güth;M. Eichholzer
背景绝经过渡期激素水平的波动可能增加易感妇女抑郁的易感性。因此，它是感兴趣的天然雌激素，如植物雌激素对抑郁症的风险在围绝经期women.MethodsOur分析包括193围绝经期妇女的国家健康与营养调查（NHANES）2005-2008年45-55岁的影响。采用HPLC-APPI-MS/MS法测定尿中植物雌激素的浓度。使用患者健康问卷-9（PHQ-9）评估抑郁症。Logistic回归模型研究的植物雌激素浓度（肌酐标准化和对数转换）与抑郁症（是/否）的关联（是/否）。结果未调整的比值比（OR）之间的关联尿植物雌激素浓度和围绝经期抑郁症低于1，但是，只有木脂素与抑郁症呈显著负相关。在多变量分析中，包括年龄、种族、体重指数、贫困收入比、吸烟、饮酒、癌症、糖尿病和心血管疾病，后一项发现没有减弱（木脂素类：OR=0.66; 95% CI 0.50-0.87;肠二醇：OR=0.63; 95% CI 0.51-0.78;肠内酯：OR=0.75; 95%CI 0.60-0.93）。局限性我们的横断面研究设计不允许因果推断。由于信息，以准确评估围绝经期症状是失踪，我们定义围绝经期妇女的年龄。ConclusionsLower木脂素，但不甾酮浓度与围绝经期妇女抑郁症的风险增加统计学显着相关。由于与使用激素治疗相关的医疗风险，有必要进一步研究木脂素对围绝经期妇女抑郁风险的影响。
BackgroundFluctuating hormonal levels observed during the menopausal transition may increase vulnerability to depression in susceptible women. Thus, it is of interest to examine the effect of natural estrogens such as phytoestrogens on the risk of depression in perimenopausal women.MethodsOur analysis included 193 perimenopausal women of the National Health and Nutrition Survey (NHANES) 2005–2008 aged 45–55 years. Urinary concentrations of phytoestrogens (isoflavones and lignans) were measured by HPLC-APPI-MS/MS. Depression was assessed using the Patient Health Questionnaire-9 (PHQ-9). Logistic regression models examined the association of phytoestrogens concentrations (creatinine-standardized and log-transformed) with depression (yes/no).ResultsUnadjusted odds ratios (OR) of the associations between urinary phytoestrogen concentrations and perimenopausal depression were below 1; however, only lignans were significantly inversely associated with depression. The latter findings were not attenuated in multivariate analysis including age, race, body mass index, poverty income ratio, smoking, alcohol consumption, cancer, diabetes, and cardiovascular disease (lignans: OR=0.66; 95% confidence intervals (CI) 0.50–0.87, enterodiol: OR=0.63; 95% CI 0.51–0.78, enterolactone: OR=0.75; 95% CI 0.60–0.93).LimitationsOur cross-sectional study design does not allow for causal inferences. Because information to precisely assess perimenopausal symptoms was missing, we defined perimenopause based on women's age.ConclusionsLower lignans but not isoflavones concentrations were statistically significantly associated with an increased risk of depression in perimenopausal women. Because of medical risks associated with the use of hormone therapy, further investigation on the effect of lignans on the risk of depression in perimenopausal women is warranted.
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影响因子：
--
作者：
Bromberger, Joyce T.;Schott, Laura L.;Kravitz, Howard M.;Sowers, MaryFran;Avis, Nancy E.;Gold, Ellen B.;Randolph, John F., Jr.;Matthews, Karen A.
通讯作者：
Matthews, Karen A.
补充植物雌激素对男性和女性认知的影响是否存在差异？
影响因子：
2.9
作者：
Sumien,Nathalie;Chaudhari,Kiran;Sidhu,Akram;Forster,MichaelJ
通讯作者：
Forster,MichaelJ
影响因子：
3.2
作者：
Gold EB
通讯作者：
Gold EB
影响因子：
--
作者：
Freeman, EW;Sammel, MD;Nelson, DB
通讯作者：
Nelson, DB
影响因子：
6.6
作者：
Bromberger, Joyce T.;Matthews, Karen A.;Randolph, John F., Jr.
通讯作者：
Randolph, John F., Jr.