Does phytoestrogen supplementation affect cognition differentially in males and females?

Does phytoestrogen supplementation affect cognition differentially in males and females?
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补充植物雌激素对男性和女性认知的影响是否存在差异?

DOI:
10.1016/j.brainres.2013.02.013
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发表时间:
2013
期刊:
影响因子:
2.9
通讯作者:
Forster,MichaelJ
Forster,MichaelJ
中科院分区:
医学3区
文献类型:
--
作者:
Sumien,Nathalie;Chaudhari,Kiran;Sidhu,Akram;Forster,MichaelJ

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植物雌激素是植物源性化合物,主要存在于大豆中,具有已知的雌激素特性,可能对人类健康有益。植物雌激素摄入量的增加源于寻找激素替代疗法的安全替代品。根据比较西方和亚洲人群的流行病学证据和临床研究,植物雌激素显示出改善健康和大脑功能的前景。本综述通过检查临床和动物研究,重点关注植物雌激素对认知的影响,特别关注(1)治疗机会窗口,这可能解释研究之间的差异,以及(2)对植物雌激素摄入的反应是否存在性别差异以及可能的潜在机制是什么。
Phytoestrogens are plant-derived compounds found mainly in soy with known estrogenic properties and a potential for benefits to human health. Increased intake in phytoestrogens stemmed from the search for safe alternatives to hormone replacement therapies. Based on epidemiologic evidence comparing Western and Asian populations and clinical studies, phytoestrogens show promise to improve health and brain function. This review is focused on the effects of phytoestrogens on cognition by examining clinical and animal studies, with special attention placed on (1) a window of therapeutic opportunity which may explain the discrepancy among studies, and (2) whether a sex/gender difference exists in response to phytoestrogen intake and what the possible underlying mechanisms may be.
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发表时间: 1998-10
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