FAAH and CNR1 Polymorphisms in the Endocannabinoid System and Alcohol-Related Sleep Quality.
FAAH and CNR1 Polymorphisms in the Endocannabinoid System and Alcohol-Related Sleep Quality.
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DOI：
10.3389/fpsyt.2021.712178
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发表时间：
2021
影响因子：
4.7
通讯作者：
Ramchandani VA
中科院分区：
文献类型：
--
作者：
Soundararajan S;Kazmi N;Brooks AT;Krumlauf M;Schwandt ML;George DT;Hodgkinson CA;Wallen GR;Ramchandani VA
睡眠障碍在酒精使用障碍（AUD）患者中很常见，短期戒酒可能无法完全解决，可能会导致饮酒复发。内源性大麻素系统（ECS）与睡眠和饮酒有关，ECS的遗传变异可能是AUD患者睡眠相关表型的基础。在这项研究中，我们探讨了ECS（大麻素受体1/CNR 1：rs 806368，rs 1049353，rs6454674，rs 2180619和脂肪酸酰胺水解酶/FAAH rs324420）中遗传变异对AUD（N = 497）和对照组（N = 389）睡眠质量的影响。我们评估了两组基线时的主观睡眠质量（来自匹兹堡睡眠质量指数/PSQI），以及基线时和住院治疗4周后AUD患者子集的客观睡眠效率和持续时间（使用体动记录仪）。我们观察到AUD和对照组的饮酒量和睡眠质量之间存在剂量依赖关系。睡眠障碍是PSQI中的一个子量表指标，在AUD（p = 0.015）和对照组（p = 0.016）中，CNR 1 rs6454674基因型之间存在显着差异。只有在对照组中，神经质人格评分介导基因型和睡眠障碍之间的关系。客观睡眠测量（睡眠效率、清醒发作和入睡后清醒），根据CNR 1 rs 806368基因型差异显着，均在基线时（分别为p = 0.023、0.029、0.015）和随访时（分别为p = 0.004，p = 0.006，p = 0.007），以及随访时体动记录仪记录的睡眠持续时间的FAAH基因型（p = 0.018）。这些关系表明ECS在酒精相关睡眠表型中的重要作用。
Sleep disturbances are common among individuals with alcohol use disorder (AUD) and may not resolve completely with short-term abstinence from alcohol, potentially contributing to relapse to drinking. The endocannabinoid system (ECS) is associated with both sleep and alcohol consumption, and genetic variation in the ECS may underlie sleep-related phenotypes among individuals with AUD. In this study, we explored the influence of genetic variants in the ECS (Cannabinoid receptor 1/CNR1: rs806368, rs1049353, rs6454674, rs2180619, and Fatty Acid Amide Hydrolase/FAAH rs324420) on sleep quality in individuals with AUD (N = 497) and controls without AUD (N = 389). We assessed subjective sleep quality (from the Pittsburgh Sleep Quality Index/PSQI) for both groups at baseline and objective sleep efficiency and duration (using actigraphy) in a subset of individuals with AUD at baseline and after 4 weeks of inpatient treatment. We observed a dose-dependent relationship between alcohol consumption and sleep quality in both AUD and control groups. Sleep disturbance, a subscale measure in PSQI, differed significantly among CNR1 rs6454674 genotypes in both AUD (p = 0.015) and controls (p = 0.016). Only among controls, neuroticism personality scores mediated the relationship between genotype and sleep disturbance. Objective sleep measures (sleep efficiency, wake bouts and wake after sleep onset), differed significantly by CNR1 rs806368 genotype, both at baseline (p = 0.023, 0.029, 0.015, respectively) and at follow-up (p = 0.004, p = 0.006, p = 0.007, respectively), and by FAAH genotype for actigraphy recorded sleep duration at follow-up (p = 0.018). These relationships suggest a significant role of the ECS in alcohol-related sleep phenotypes.
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影响因子：
4.7
作者：
Elkrief L;Spinney S;Vosberg DE;Banaschewski T;Bokde ALW;Quinlan EB;Desrivières S;Flor H;Garavan H;Gowland P;Heinz A;Brühl R;Martinot JL;Paillère Martinot ML;Nees F;Papadopoulos Orfanos D;Poustka L;Hohmann S;Millenet S;Fröhner JH;Smolka MN;Walter H;Whelan R;Schumann G;Pausova Z;Paus T;Huguet G;Conrod P;IMAGEN consortium
通讯作者：
IMAGEN consortium
影响因子：
4.8
作者：
Grandner, Michael A.;Patel, Nirav P.;Gehrman, Philip R.;Xie, Dawei;Sha, Daohang;Weaver, Terri;Gooneratne, Nalaka
通讯作者：
Gooneratne, Nalaka
影响因子：
4.6
作者：
Britton, Annie;Fat, Linda Ng;Neligan, Aidan
通讯作者：
Neligan, Aidan
影响因子：
5.8
作者：
Doris, Joseph M.;Millar, Sophie A.;O'Sullivan, Saoirse E.
通讯作者：
O'Sullivan, Saoirse E.
影响因子：
4.7
作者：
Backhaus, J;Junghanns, K;Hohagen, F
通讯作者：
Hohagen, F