Prefrontal dysfunction in pediatric Tourette's disorder as measured by near-infrared spectroscopy.
Prefrontal dysfunction in pediatric Tourette's disorder as measured by near-infrared spectroscopy.
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DOI：
10.1186/s12888-015-0472-3
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发表时间：
2015-05-03
期刊：
影响因子：
4.4
通讯作者：
Kishimoto T
中科院分区：
文献类型：
--
作者：
Yamamuro K;Ota T;Iida J;Nakanishi Y;Uratani M;Matsuura H;Kishimoto N;Tanaka S;Negoro H;Kishimoto T
抽动秽语障碍（TD）是一种慢性儿童期发作的疾病，其特征是存在多种运动和发声抽搐。尽管有强有力的证据表明，TD的病理生理学涉及基底神经节和皮质额叶区的结构和功能障碍，在体内成像研究产生了相互矛盾的结果。近红外光谱（NIRS）技术的最新发展使无创评估精神疾病患者的脑功能成为可能。我们要求10名年龄和性别匹配的儿童TD患者和10名健康对照者在NIRS期间执行Stroop颜色词任务。我们使用前额叶探头和24通道近红外光谱仪测量氧合血红蛋白（oxy-Hb）的相对浓度，每0.1秒的任务。我们发现，氧血红蛋白的变化在前额叶皮层的TD组与对照组相比，显着较小，尤其是在左背外侧前额叶皮层。我们的数据表明，个体与小儿TD有一个减少前额叶血流动力学反应的近红外光谱测量。
Tourette’s disorder (TD) is a chronic childhood-onset disorder characterized by the presence of multiple motor and vocal tics. Despite strong evidence that the pathophysiology of TD involves structural and functional disturbances of the basal ganglia and cortical frontal areas, in vivo imaging studies have produced conflicting results. Recent developments in near-infrared spectroscopy (NIRS) technology have enabled noninvasive assessment of brain function in people with psychiatric disorders. We asked 10 individuals with pediatric TD and 10 healthy controls who were age- and sex- matched to perform the Stroop color-word task during NIRS. We used prefrontal probes and a 24-channel NIRS machine to measure the relative concentrations of oxyhemoglobin (oxy-Hb) every 0.1 s during the task. We found that oxy-Hb changes in the prefrontal cortex were significantly smaller in the TD group compared with the control group, especially in the left dorsolateral prefrontal cortex. Our data suggest that individuals with pediatric TD have a reduced prefrontal hemodynamic response as measured by NIRS.
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