Yeast systems biology: the challenge of eukaryotic complexity.

Yeast systems biology: the challenge of eukaryotic complexity.
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酵母系统生物学:真核复杂性的挑战。

DOI:
10.1007/978-1-61779-173-4_1
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发表时间:
2011
期刊:
Methods in molecular biology (Clifton, N.J.)
影响因子:
--
通讯作者:
Castrillo JI
Castrillo JI
中科院分区:
--
文献类型:
--
作者:
Castrillo JI

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在这一章中,我们提出了一个最新的观点的最佳特性的酵母Saccharomycescleae作为一个模型真核生物系统生物学研究,主要的分子机制,生物网络,和亚细胞组织基本上保守的所有真核生物,来自一个复杂的共同祖先。先进的分子研究工具以及高通量实验和计算方法的存在,其中大部分正在酵母中实施和验证,新的正在开发中,为所有真核生物所必需的核心模块化架构和复杂网络的表征开辟了道路。本书介绍了以酵母为参考模型的真核生物复杂性和系统生物学研究的最新发现及其在生物技术和医学中的应用。
In this chapter, we present an up-to-date view of the optimal characteristics of the yeastSaccharomyces cerevisiaeas a model eukaryote for systems biology studies, with main molecular mechanisms, biological networks, and sub-cellular organization essentially conserved in all eukaryotes, derived from a complex common ancestor. The existence of advanced tools for molecular studies together with high-throughput experimental and computational methods, most of them being implemented and validated in yeast, with new ones being developed, is opening the way to the characterization of the core modular architecture and complex networks essential to all eukaryotes. Selected examples of the latest discoveries in eukaryote complexity and systems biology studies using yeast as a reference model and their applications in biotechnology and medicine are presented.
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