MicroRNA in teleost fish.

MicroRNA in teleost fish.
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DOI:
10.1093/gbe/evu151
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发表时间:
2014-07-22
影响因子:
3.3
通讯作者:
Babiak I
Babiak I
中科院分区:
生物学2区
文献类型:
--
作者:
Bizuayehu TT;Babiak I

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微小RNA(microRNAs,miRNAs)是一种转录和转录后调节因子,参与远缘真核生物进化枝中几乎所有已知的生物学过程。它们的发现和功能表征拓宽了我们对动物和植物生物调节机制的理解。它们在后生动物中表现出进化上的保守性和独特性。在这里,我们提出了目前的知识状态的作用,miRNA的发育,生长和生理的硬骨鱼,与其他脊椎动物相比。真骨下纲是脊椎动物中最丰富的类群。鱼类是水生生态系统和人类生活的重要组成部分,是全世界动物蛋白质的丰富来源,也是生物医学研究的脊椎动物模型。本文综述了miRNA的生物发生、调控、修饰和作用机制。具体部分致力于miRNA在硬骨鱼发育,器官发生,组织分化,生长,再生,生殖,内分泌系统和对环境刺激的反应中的作用。每个部分讨论了目前知识的差距,并指出了未来的研究方向在硬骨鱼miRNA。
MicroRNAs (miRNAs) are transcriptional and posttranscriptional regulators involved in nearly all known biological processes in distant eukaryotic clades. Their discovery and functional characterization have broadened our understanding of biological regulatory mechanisms in animals and plants. They show both evolutionary conserved and unique features across Metazoa. Here, we present the current status of the knowledge about the role of miRNA in development, growth, and physiology of teleost fishes, in comparison to other vertebrates. Infraclass Teleostei is the most abundant group among vertebrate lineage. Fish are an important component of aquatic ecosystems and human life, being the prolific source of animal proteins worldwide and a vertebrate model for biomedical research. We review miRNA biogenesis, regulation, modifications, and mechanisms of action. Specific sections are devoted to the role of miRNA in teleost development, organogenesis, tissue differentiation, growth, regeneration, reproduction, endocrine system, and responses to environmental stimuli. Each section discusses gaps in the current knowledge and pinpoints the future directions of research on miRNA in teleosts.
DOI: 10.1093/molbev/msl049
发表时间: 2006-09-01
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发表时间: 2012-01-01
期刊: SEXUAL DEVELOPMENT
影响因子: 2.3
作者:
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通讯作者: Babiak, I.