Assessment of prenatal exposure to tobacco smoke by cotinine in cord blood for the evaluation of smoking control policies in Spain.
Assessment of prenatal exposure to tobacco smoke by cotinine in cord blood for the evaluation of smoking control policies in Spain.
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DOI：
10.1186/1471-2393-12-26
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发表时间：
2012-04-05
影响因子：
3.1
通讯作者：
Villalbí JR
中科院分区：
文献类型：
--
作者：
Puig C;Vall O;García-Algar O;Papaseit E;Pichini S;Saltó E;Villalbí JR
在过去的几年里，吸烟的趋势不仅出现在普通人群中，而且在怀孕期间也出现了减少的趋势。一些国家实施了法律，要求所有封闭的工作场所和公共场所不得有二手烟(SHS)。在西班牙，2005年实施了减少SHS的立法。本研究考察了这项立法对产前SHS暴露的可能影响。母亲和新生儿是从在德尔玛医院(巴塞罗那)进行并得到当地道德委员会批准的3项独立研究中招募的：415人参加了1996-1998年的一项研究，283人参加了2002-2004年的研究，207人参加了2008年的研究。三个研究组的所有参与者在分娩时完成了一份标准问卷，包括新生儿和社会人口学变量、烟草使用和孕期暴露。采用放射免疫分析法(RIA)测定胎儿脐带血中的可替宁，以了解胎儿对烟草的暴露情况。32.8%的孕妇报告在怀孕期间吸烟，2002-2004年和2008年分别为25.9%和34.1%。在最近一组中，与前两组相比，无产前SHS暴露(脐带血Cotinine 0.2-1 ng/mL)的百分比有所增加，而产前SHS暴露较低(1.1-14 ng/mL)和非常高(>；100 ng/mL)的百分比均有所下降。三个研究期(1996-2008年)的结果表明，没有接触SHS的新生儿百分比显著增加，而在怀孕期间接触SHS的新生儿百分比下降，特别是在极高水平的暴露下。在这一地理区域发现了一个重要的母亲吸烟习惯，特别强调移民怀孕吸烟妇女。我们的研究表明，在这个地理区域，母亲有很大的吸烟习惯。我们的建议是，禁烟运动应更具体地针对孕妇，特别强调非本地孕妇吸烟者，因为在移民妇女中烟草消费的流行率最高。
Over the last few years a decreasing trend in smoking has occurred not only in the general population but also during pregnancy. Several countries have implemented laws requiring all enclosed workplace and public places to be free of second hand smoke (SHS). In Spain, legislation to reduce SHS was implemented in 2005. The present study examines the possible effect of this legislation on prenatal SHS exposure. Mothers and newborns were recruited from 3 independent studies performed in Hospital del Mar (Barcelona) and approved by the local Ethics Committee: 415 participated in a study in 1996-1998, 283 in 2002-2004 and 207 in 2008. A standard questionnaire, including neonatal and sociodemographic variables,tobacco use and exposure during pregnancy, was completed at delivery for all the participants in the three study groups. Fetal exposure to tobacco was studied by measuring cotinine in cord blood by radioimmunoassay (RIA). 32.8% of the pregnant women reported to smoke during pregnancy in 1996-1998, 25.9% in 2002-2004 and 34.1% in 2008. In the most recent group, the percentage of no prenatal SHS exposure (cord blood cotinine 0.2-1 ng/mL) showed an increase compared to the previous groups while the percentages of both: low (1.1-14 ng/mL) and very high (> 100 ng/mL) prenatal SHS exposure showed a decrease. The results of the three study periods (1996-2008) demonstrated a significant increase in the percentage of newborns free from SHS exposure and a decrease in the percentage of newborns exposed to SHS during pregnancy, especially at the very high levels of exposure. A significant maternal smoking habit was noted in this geographical area with particular emphasis on immigrant pregnant smoking women. Our study indicates that there is a significant maternal smoking habit in this geographical area. Our recommendation is that campaigns against smoking should be directed more specifically towards pregnant women with particular emphasis on non-native pregnant smokers due to the highest prevalence of tobacco consumption in the immigrant women.
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影响因子：
3.2
作者：
de Chazeron, Ingrid;Daval, Sandrine;Coudore, Francois
通讯作者：
Coudore, Francois
影响因子：
8
作者：
Friguls, Bibiana;Garcia-Algar, Oscar;Vall, Oriol
通讯作者：
Vall, Oriol
影响因子：
105.7
作者：
Akhtar, Patricia C.;Currie, Dorothy B.;Haw, Sally J.
通讯作者：
Haw, Sally J.
影响因子：
5.5
作者：
Castles, A;Adams, EK;Boulton, ML
通讯作者：
Boulton, ML
影响因子：
2.1
作者：
Garcia-Algar, O.;Vall Combelles, O.;Pichini, S.
通讯作者：
Pichini, S.