Chemotherapy intensity and toxicity among black and white women with advanced and recurrent endometrial cancer: a Gynecologic Oncology Group Study.
Chemotherapy intensity and toxicity among black and white women with advanced and recurrent endometrial cancer: a Gynecologic Oncology Group Study.
复制标题
DOI：
10.1002/cncr.24769
复制
发表时间：
2010-01-15
期刊：
影响因子：
6.2
通讯作者：
Maxwell, G. Larry
中科院分区：
文献类型：
--
作者：
Farley, John H.;Tian, Chunqiao;Rose, G. Scott;Brown, Carol L.;Birrer, Michael;Risinger, John I.;Thigpen, J. Tate;Fleming, Gini F.;Gallion, Holly H.;Maxwell, G. Larry
本研究的目的是确认患有子宫内膜癌的黑人和白色女性是否对化疗具有同等耐受性，并确定影响生存率的因素。对169名黑人妇女和982名白色妇女FIGO III/IV期或复发性子宫内膜癌进行了回顾性分析。所有患者均接受阿霉素联合顺铂治疗。回顾的化疗参数包括相对剂量（RD）、相对时间（RT）和相对剂量强度（RDI）。治疗周期≥ 7定义为治疗完成。尽管黑人患者更可能发生3-4级贫血（20% vs. 14%）和泌尿生殖系统（5% vs. 1%）毒性，并且不太可能发生重度GI毒性（10% vs. 17%），但两组之间3-4级治疗相关化学毒性的总体发生率相同（82% vs. 82%）。黑人和白色患者接受的周期数、RD（0.57 vs. 0.58）、RT（0.77 vs. 0.78）或RDI（0.76 vs. 0.76）无差异。与白色患者相比，接受四种GOG方案治疗的晚期或复发性子宫内膜癌黑人患者具有相似的剂量强度和严重的化疗相关毒性，这表明先前描述的GOG试验中患者生存率的种族差异可能具有新的病因。
The purpose of this study was to confirm whether Black and White women with endometrial cancer are equally tolerant of chemotherapy and identify factors that impact survival. A retrospective review of 169 Black women and 982 White women with FIGO Stage III/IV or recurrent endometrial carcinoma was performed. All patients received doxorubicin combined with cisplatin. Chemotherapy parameters that were reviewed included relative dose (RD), relative time (RT), and relative dose intensity (RDI). Treatment cycles ≥ 7 were defined as treatment completion. Although Black patients were more likely to experience grade 3-4 anemia (20% vs. 14%) and genitourinary (5% vs. 1%) toxicity, and less likely to experience severe GI toxicity (10% vs. 17%), the overall incidence of grade 3-4 treatment-related chemotoxicity was the same between the two groups (82% vs. 82%). There were no differences in the number of cycles received, RD (0.57 vs. 0.58), RT (0.77 vs. 0.78), or RDI (0.76 vs. 0.76) for Black and White patients. Black patients with advanced stage or recurrent endometrial cancer, treated on four GOG protocols, had similar dose intensity and severe chemotherapy-related toxicity compared to White patients, suggesting that previously described racial disparities in survival among patients in GOG trials may have an novel etiology.
登录
查看更多内容
DOI：
10.1016/s0002-9378(97)70380-6
发表时间：
1997-06-01
影响因子：
9.8
作者：
Clifford, SL;Kaminetsky, CP;Berchuck, A
通讯作者：
Berchuck, A
影响因子：
6.2
作者：
Sherman, ME;Devesa, SS
通讯作者：
Devesa, SS
影响因子：
6.2
作者：
Maxwell, G. Larry;Tian, Chunqiao;Brewster, Wendy R.
通讯作者：
Brewster, Wendy R.
影响因子：
45.3
作者：
Gallion, HH;Brunetto, VL;Andersen, W
通讯作者：
Andersen, W
影响因子：
4.7
作者：
Lambrou, N;Trimble, E L
通讯作者：
Trimble, E L