Neurodegeneration, Alzheimer's disease biomarkers, and longitudinal verbal learning and memory performance in late middle age.
Neurodegeneration, Alzheimer's disease biomarkers, and longitudinal verbal learning and memory performance in late middle age.
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DOI：
10.1016/j.neurobiolaging.2021.01.030
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发表时间：
2021-06
影响因子：
4.2
通讯作者：
Johnson SC
中科院分区：
文献类型：
--
作者：
Allison SL;Jonaitis EM;Koscik RL;Hermann BP;Mueller KD;Cary RP;Ma Y;Rowley HA;Carlsson CM;Asthana S;Zetterberg H;Blennow K;Bendlin BB;Johnson SC
This study examined the effect of neurodegeneration, and its interaction table 5 with Alzheimer’s disease (AD) cerebrospinal fluid (CSF) biomarkers, on longitudinal verbal learning and memory performance in cognitively unimpaired (CU) late middle-aged adults. Three hundred and forty-two CU adults (cognitive baseline mean age=58.4), with CSF and structural MRI, completed 2–10 (median=5) cognitive assessments. Learning and memory were assessed using the Rey Auditory Verbal Learning Test (RAVLT). We used sequential comparison of nested linear mixed effects models to analyze the data. Model selection preserved a significant ptau181/Aβ42 × global atrophy × age interaction; individuals with less global atrophy and lower ptau181/Aβ42 levels had less learning and delayed recall decline than individuals with more global atrophy and/or higher levels of ptau181/Aβ42. The hippocampal volume x age x ptau181/Aβ42 interaction was not significant. Findings suggest that in a sample of CU late middle-aged adults, individuals with AD biomarkers, global atrophy, or both evidence greater verbal learning and memory decline than individuals without either risk factor.
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影响因子：
3
作者：
AKAIKE, H
通讯作者：
AKAIKE, H
影响因子：
38.1
作者：
Frisoni, Giovanni B.;Fox, Nick C.;Jack, Clifford R., Jr.;Scheltens, Philip;Thompson, Paul M.
通讯作者：
Thompson, Paul M.
DOI：
10.1016/j.dadm.2016.09.002
发表时间：
2017
期刊：
Alzheimer's & dementia (Amsterdam, Netherlands)
影响因子：
--
作者：
Baker JE;Lim YY;Pietrzak RH;Hassenstab J;Snyder PJ;Masters CL;Maruff P
通讯作者：
Maruff P
影响因子：
--
作者：
Fotenos, Anthony F.;Mintun, Mark A.;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
影响因子：
4.2
作者：
Bouwman, F. H. f;Schoonenboom, S. N. M.;Scheltens, Ph
通讯作者：
Scheltens, Ph