Up-regulation of insulin-like growth factor 2 by ketamine requires glycogen synthase kinase-3 inhibition.
Up-regulation of insulin-like growth factor 2 by ketamine requires glycogen synthase kinase-3 inhibition.
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DOI：
10.1016/j.pnpbp.2016.08.008
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发表时间：
2017-01-04
影响因子：
5.6
通讯作者：
Beurel, Eleonore
中科院分区：
文献类型：
--
作者：
Grieco, Steven F.;Cheng, Yuyan;Eldar-Finkelman, Hagit;Jope, Richard S.;Beurel, Eleonore
关键词：
抗抑郁剂量的速效氯胺酮抑制小鼠海马中的糖原合成酶激酶-3（GSK 3），并且这种抑制是氯胺酮在习得性无助抑郁样行为中的抗抑郁作用所必需的。在这里，我们报告了用抗抑郁剂量的氯胺酮（10 mg/kg）治疗增加了小鼠海马中胰岛素样生长因子2（IGF 2）的表达，这种作用需要氯胺酮诱导的GSK 3抑制。氯胺酮也抑制海马GSK 3和海马IGF 2的表达增加时，诱导后的习得性无助的小鼠。用特异性GSK 3抑制剂L 803-mts治疗足以上调海马IGF 2表达。IGF 2 siRNA的施用降低了氯胺酮在习得性无助范例中的抗抑郁作用。接受习得性无助模式的小鼠被分成两组，那些有弹性的（非抑郁）和那些易受影响的（抑郁）。非抑郁恢复性小鼠比易感小鼠显示出更高的IGF 2表达。这些结果表明，IGF 2有助于氯胺酮的抗抑郁作用，IGF 2可能赋予抑郁样行为的弹性。
An antidepressant dose of the rapidly-acting ketamine inhibits glycogen synthase kinase-3 (GSK3) in mouse hippocampus, and this inhibition is required for the antidepressant effect of ketamine in learned helplessness depression-like behavior. Here we report that treatment with an antidepressant dose of ketamine (10 mg/kg) increased expression of insulin-like growth factor 2 (IGF2) in mouse hippocampus, an effect that required ketamine-induced inhibition of GSK3. Ketamine also inhibited hippocampal GSK3 and increased expression of hippocampal IGF2 in mice when administered after the induction of learned helplessness. Treatment with the specific GSK3 inhibitor L803-mts was sufficient to up-regulate hippocampal IGF2 expression. Administration of IGF2 siRNA reduced ketamine's antidepressant effect in the learned helplessness paradigm. Mice subjected to the learned helplessness paradigm were separated into two groups, those that were resilient (non-depressed) and those that were susceptible (depressed). Non-depressed resilient mice displayed higher expression of IGF2 than susceptible mice. These results indicate that IGF2 contributes to ketamine's antidepressant effect and that IGF2 may confer resilience to depression-like behavior.
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影响因子：
64.8
作者：
Autry, Anita E.;Adachi, Megunai;Nosyreva, Elena;Na, Elisa S.;Los, Maarten F.;Cheng, Peng-fei;Kavalali, Ege T.;Monteggia, Lisa M.
通讯作者：
Monteggia, Lisa M.
DOI：
10.1126/science.1190287
发表时间：
2010-08-20
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Li N;Lee B;Liu RJ;Banasr M;Dwyer JM;Iwata M;Li XY;Aghajanian G;Duman RS
通讯作者：
Duman RS
影响因子：
--
作者：
LAUTERIO, TJ;RIEG, TS;ARAVICH, PF
通讯作者：
ARAVICH, PF
胰岛素样生长因子 2 可减轻慢性应激大鼠模型的抑郁行为
影响因子：
4.7
作者：
Luo, Yan-Wei;Xu, Yang;Li, Chang-Qi
通讯作者：
Li, Chang-Qi
影响因子：
6.8
作者：
Córdova-Palomera A;Fatjó-Vilas M;Gastó C;Navarro V;Krebs MO;Fañanás L
通讯作者：
Fañanás L