The genomic signal of partial sweeps in Mimulus guttatus.
The genomic signal of partial sweeps in Mimulus guttatus.
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DOI：
10.1093/gbe/evt100
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发表时间：
2013
影响因子：
3.3
通讯作者：
Mojica JP
中科院分区：
文献类型：
--
作者：
Kelly JK;Koseva B;Mojica JP
选择的分子特征在很大程度上取决于新的突变是否立即有利并扫描到固定（硬扫描），而不是选择作用于分离变异（软扫描）。对所选多态性周围序列变异减少的预测对于硬扫描比软扫描强得多，特别是当考虑扫描可能不完整的数量性状时。在这里，我们直接调查的基因组信号的软扫描内的人工选择实验Mimulus guttatus。首先，我们开发了一种统计方法的基础上费舍尔的角度变换的等位基因频率，以确定选定的基因座。该方法的应用确定了约400个显著窗口，但在表型不同的群体之间没有固定的差异。有两个显着的例外，我们发现一个温和的平均效应的部分扫描分子的变化量。第一个例外是6号染色体上的多态倒位。衍生的单倍型的增加具有广泛的基因组效应，这是由于重组抑制与群体内的基本初始单倍型结构相结合。第二，我们发现在进化较大花朵的种群中，所选基因座周围的核苷酸变异显著增加。这表明花大小的“高”等位基因最初比“低”等位基因频率低。这一结果与M. guttatus和说明如何分子进化可以依赖于数量性状基因座的等位基因频率谱。
The molecular signature of selection depends strongly on whether new mutations are immediately favorable and sweep to fixation (hard sweeps) as opposed to when selection acts on segregating variation (soft sweeps). The prediction of reduced sequence variation around selected polymorphisms is much stronger for hard than soft sweeps, particularly when considering quantitative traits where sweeps are likely to be incomplete. Here, we directly investigate the genomic signal of soft sweeps within an artificial selection experiment on Mimulus guttatus. We first develop a statistical method based on Fisher’s angular transformation of allele frequencies to identify selected loci. Application of this method identifies about 400 significant windows, but no fixed differences between phenotypically divergent populations. With two notable exceptions, we find a modest average effect of partial sweeps on the amount of molecular variation. The first exception is a polymorphic inversion on chromosome 6. The increase of the derived haplotype has a broad genomic effect due to recombination suppression coupled with substantial initial haplotype structure within the population. Second, we found significant increases in nucleotide variation around selected loci in the population evolving larger flowers. This suggests that “high” alleles for flower size were initially less frequent than “low” alleles. This result is consistent with prior studies of M. guttatus and illustrates how molecular evolution can depend on the allele frequency spectrum at quantitative trait loci.
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影响因子：
2.3
作者：
Hohenlohe PA;Phillips PC;Cresko WA
通讯作者：
Cresko WA
DOI：
10.1073/pnas.0401720101
发表时间：
2004-07-20
影响因子：
11.1
作者：
Innan, H;Kim, Y
通讯作者：
Kim, Y
影响因子：
3.3
作者：
COHAN, FM
通讯作者：
COHAN, FM
影响因子：
3.3
作者：
Goldringer, I;Bataillon, T
通讯作者：
Bataillon, T
影响因子：
4.5
作者：
Johansson AM;Pettersson ME;Siegel PB;Carlborg O
通讯作者：
Carlborg O