Higher SARS-CoV-2 seroprevalence in workers with lower socioeconomic status in Cape Town, South Africa.
Higher SARS-CoV-2 seroprevalence in workers with lower socioeconomic status in Cape Town, South Africa.
复制标题
DOI：
10.1371/journal.pone.0247852
复制
发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Walzl G
中科院分区：
文献类型：
--
作者：
Shaw JA;Meiring M;Cummins T;Chegou NN;Claassen C;Du Plessis N;Flinn M;Hiemstra A;Kleynhans L;Leukes V;Loxton AG;MacDonald C;Mtala N;Reuter H;Simon D;Stanley K;Tromp G;Preiser W;Malherbe ST;Walzl G
不平等现象在南非普遍存在。第一波COVID-19疫情对社会经济地位较低人群的影响可能比富裕人群更严重。南非的SARS-CoV-2血清阳性率和抗SARS-CoV-2抗体检测的特异性尚不清楚。我们使用Abbott SARS-CoV-2 IgG检测试剂盒对来自开普敦市中心一个受欢迎的购物和旅游综合体的405名志愿者进行了测试，这些志愿者代表了所有社会经济阶层。我们评估了抗体阳性与COVID-19症状状态、病史和社会人口变量之间的关联。我们检测了COVID-19大流行前在开普敦采集的137份健康对照血清样本，以确认该检测方法在当地人群中的特异性。在开普敦疫情第一个高峰后一个月，405名志愿者接受了检测，其中96人（23.7%）为SARS-CoV-2 IgG阳性。在检测呈阳性的人中，46人（47.9%）在过去6个月内没有报告COVID-19症状。血清阳性与居住在非正规住房、居住在每户收入低的分区以及从事低收入职业显著相关。在前COVID对照中，该测定的特异性为98.54%（95%CI 94.82%-99.82%）。开普敦的背景血清阳性率很高，特别是在社会经济地位较低的人群中。几乎一半的病例无症状，因此未被当地检测策略确诊。这些结果不能用低检测特异性来解释。
Inequality is rife throughout South Africa. The first wave of COVID-19 may have affected people in lower socioeconomic groups worse than the affluent. The SARS-CoV-2 seroprevalence and the specificity of anti-SARS-CoV-2 antibody tests in South Africa is not known. We tested 405 volunteers representing all socioeconomic strata from the workforce of a popular shopping and tourist complex in central Cape Town with the Abbott SARS-CoV-2 IgG assay. We assessed the association between antibody positivity and COVID-19 symptom status, medical history, and sociodemographic variables. We tested 137 serum samples from healthy controls collected in Cape Town prior to the COVID-19 pandemic, to confirm the specificity of the assay in the local population. Of the 405 volunteers tested one month after the first peak of the epidemic in Cape Town, 96(23.7%) were SARS-CoV-2 IgG positive. Of those who tested positive, 46(47.9%) reported no symptoms of COVID-19 in the previous 6 months. Seropositivity was significantly associated with living in informal housing, residing in a subdistrict with low income-per household, and having a low-earning occupation. The specificity of the assay was 98.54%(95%CI 94.82%-99.82%) in the pre-COVID controls. There is a high background seroprevalence in Cape Town, particularly in people of lower socioeconomic status. Almost half of cases are asymptomatic, and therefore undiagnosed by local testing strategies. These results cannot be explained by low assay specificity.
登录
查看更多内容
DOI：
10.1016/j.ijid.2020.10.104
发表时间：
2021-01
期刊：
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
影响因子：
--
作者：
Tso FY;Lidenge SJ;Peña PB;Clegg AA;Ngowi JR;Mwaiselage J;Ngalamika O;Julius P;West JT;Wood C
通讯作者：
Wood C
影响因子：
29.9
作者：
Jay J;Bor J;Nsoesie EO;Lipson SK;Jones DK;Galea S;Raifman J
通讯作者：
Raifman J
影响因子：
9.3
作者：
Whittle, Richard S.;Diaz-Artiles, Ana
通讯作者：
Diaz-Artiles, Ana
影响因子：
9.4
作者：
Theel, Elitza S.;Harring, Julie;Granger, Dane
通讯作者：
Granger, Dane
DOI：
10.1016/s1473-3099(20)30634-4
发表时间：
2020-12
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
National SARS-CoV-2 Serology Assay Evaluation Group
通讯作者：
National SARS-CoV-2 Serology Assay Evaluation Group