A wearable electrochemical biosensor for the monitoring of metabolites and nutrients.
A wearable electrochemical biosensor for the monitoring of metabolites and nutrients.
复制标题
一种可穿戴的电化学生物传感器，用于监测代谢物和营养物质。
DOI：
10.1038/s41551-022-00916-z
复制
发表时间：
2022-11
影响因子：
28.1
通讯作者：
Gao, Wei
中科院分区：
文献类型：
--
作者：
Wang, Minqiang;Yang, Yiran;Min, Jihong;Song, Yu;Tu, Jiaobing;Mukasa, Daniel;Ye, Cui;Xu, Changhao;Heflin, Nicole;McCune, Jeannine S.;Hsiai, Tzung K.;Li, Zhaoping;Gao, Wei
用于连续监测汗液中代谢物的可穿戴非侵入式生物传感器可以检测足够高浓度的一些分析物，通常在剧烈运动期间，以便产生足够量的生物流体。在这里，我们报告了一种可穿戴电化学生物传感器的设计和性能，用于在体育锻炼和休息期间在汗液中连续分析多种代谢物和营养物质的痕量水平，包括所有必需氨基酸和维生素。该生物传感器由石墨烯电极组成，石墨烯电极可以在原位重复再生，用代谢物特异性抗体样分子印迹聚合物和氧化还原活性报告纳米颗粒功能化，并与基于离子电渗的汗液诱导，微流体汗液采样，信号处理和校准以及无线通信的模块集成。在志愿者中，生物传感器能够实时监测身体锻炼期间氨基酸的摄入量及其水平，以及评估代谢综合征的风险（通过将血清和汗液中的氨基酸水平相关联）。监测代谢物以早期识别异常健康状况可以促进精确营养的应用。
Wearable non-invasive biosensors for the continuous monitoring of metabolites in sweat can detect a few analytes at sufficiently high concentrations, typically during vigorous exercise so as to generate sufficient quantity of the biofluid. Here, we report the design and performance of a wearable electrochemical biosensor for the continuous analysis, in sweat during physical exercise and at rest, of trace levels of multiple metabolites and nutrients, including all essential amino acids and vitamins. The biosensor consists of graphene electrodes that can be repeatedly regenerated in situ, functionalized with metabolite-specific antibody-like molecularly imprinted polymers and redox-active reporter nanoparticles, and integrated with modules for iontophoresis-based sweat induction, microfluidic sweat sampling, signal processing and calibration, and wireless communication. In volunteers, the biosensor enabled the real-time monitoring of the intake of amino acids and their levels during physical exercise, as well as the assessment of the risk of metabolic syndrome (by correlating amino acid levels in serum and sweat). The monitoring of metabolites for the early identification of abnormal health conditions could facilitate applications in precision nutrition.
登录
查看更多内容
影响因子：
17.1
作者：
Koh A;Kang D;Xue Y;Lee S;Pielak RM;Kim J;Hwang T;Min S;Banks A;Bastien P;Manco MC;Wang L;Ammann KR;Jang KI;Won P;Han S;Ghaffari R;Paik U;Slepian MJ;Balooch G;Huang Y;Rogers JA
通讯作者：
Rogers JA
影响因子：
13.6
作者：
Lee H;Song C;Hong YS;Kim M;Cho HR;Kang T;Shin K;Choi SH;Hyeon T;Kim DH
通讯作者：
Kim DH
影响因子：
44.5
作者：
Ahlqvist, Emma;Storm, Petter;Groop, Leif
通讯作者：
Groop, Leif
影响因子：
4.2
作者：
Layman, DK;Walker, DA
通讯作者：
Walker, DA
用于自供电个性化医疗保健的基于无线纺织品的传感器系统
影响因子：
18.9
作者：
Meng, Keyu;Zhao, Shenlong;Chen, Jun
通讯作者：
Chen, Jun